Publications

Publications

Translational Metabolism Research Laboratory

2024

McKenna, C.F., Stierwalt, H., Zemski Berry, K.A., Ehrlicher, S.E., Robinson, M.M., Zarini, S., Kahn, D.E., Snell-Bergeon, J.K., Perreault, L., Bergman, B.C., Newsom, S.A.  (2024)  Intramuscular diacylglycerol accumulates with acute hyperinsulinemia in insulin-resistant phenotypes  American journal of physiology. Endocrinology and metabolism.  

2023

Batterson, P.M., McGowan, E.M., Borowik, A.K., Kinter, M.T., Miller, B.F., Newsom, S.A., Robinson, M.M.  (2023)  High‐fat diet increases electron transfer flavoprotein synthesis and lipid respiration in skeletal muscle during exercise training in female mice  Physiological Reports  11(20)
Batterson, P.M., McGowan, E.M., Stierwalt, H., Ehrlicher, S.E., Newsom, S.A., Robinson, M.M.  (2023)  Two weeks of high-intensity interval training increases skeletal muscle mitochondrial respiration via complex-specific remodeling in sedentary humans  Journal ofApplied Physiology  134(2)

2022

McGowan, E.M., Ehrlicher, S.E., Stierwalt, H., Robinson, M.M., Newsom, S.A.  (2022)  Impact of 4 weeks of western diet and aerobic exercise training on whole‐body phenotype and skeletal muscle mitochondrial respiration in male and female mice  Physiological Reports  10(24)
Zhang, X., Habiballa, L., Aversa, Z., Ng, Y.E., Sakamoto, A.E., Englund, D.A., Pearsall, V.M., White, T.A., Robinson, M.M., Rivas, D.A., Dasari, S., Hruby, A., Lagnado, A.B., Jachim, S.K., Granic, A., Sayer, A.A., Jurk, D., Lanza, I.R., Khosla, S., Fielding, R.A., Nair, K.S., Schafer, M.J., Passos, J.F., LeBrasseur, N.K.  (2022)  Characterization of cellular senescence in aging skeletal muscle  Nature Aging  2
Pataky, M.W., Kumar, A.P., Robinson, M.M., Klaus, K.A., Dasari, S., Nair, K.S.  (2022)  246-OR: Role of Skeletal Muscle Branched-Chain Amino Acid Metabolism in Exercise Training–Induced Insulin Sensitivity  Diabetes  71
Koh, J., Pataky, M. W., Dasari, S., Klaus, K. A., Vučković, I., Ruegsegger, G.N., Kumar, A.P., Robinson, M.M., Nair, K.S.  (2022)  Enhancement of anaerobic glycolysis – a role of PGC-1α4 in resistance exercise  Nature Communications  13(1)

2018

Perreault, L., Newsom, S.A., Strauss, A., Kerege, A.A., Kahn, D.E., Harrison, K.A., Snell-Bergeon, J.K., Nemkov, T., D’Alessandro, A., Jackman, M.R., MacLean, P.S., Bergman, B.C.  (2018)  Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle  JCI Insight  3(3)

2013

Boyle, K.E., Newsom, S.A., Janssen, R.C., Lappas, M., Friedman, J.E.  (2013)  Skeletal muscle MnSOD, mitochondrial complex II, and SIRT3 enzyme activities are decreased in maternal obesity during human pregnancy and gestational diabetes mellitus  The Journal of Clinical Endocrinology and Metabolism  98(10)
Newsom, S.A., Everett, A.C., Hinko, A., Horowitz, J.F.  (2013)  A Single Session of Low-Intensity Exercise Is Sufficient to Enhance Insulin Sensitivity Into the Next Day in Obese Adults  Diabetes Care  36(9)

2021

Broussard JL, Perreault L, Macias E, et al. Sex Differences in Insulin Sensitivity are Related to Muscle Tissue Acylcarnitine But Not Subcellular Lipid Distribution. Obesity (Silver Spring). 2021;29(3):550-561. doi:10.1002/oby.23106. PubMed: 33624435.

Ehrlicher SE, Stierwalt HD, Newsom SA, Robinson MM. Short-Term High-Fat Feeding Does Not Alter Mitochondrial Lipid Respiratory Capacity but Triggers Mitophagy Response in Skeletal Muscle of Mice. Frontiers in Endocrinology. 2021;12. doi:10.3389/fendo.2021.651211.

Keller RMoon, Beaver LM, Reardon PN, et al. Nitrate-induced improvements in exercise performance are coincident with exuberant changes in metabolic genes and the metabolome in zebrafish skeletal muscle. J Appl Physiol (1985). 2021. doi:10.1152/japplphysiol.00185.2021. PubMed: 34043471.

Zhang Y, Bobe G, Miranda CL, et al. Tetrahydroxanthohumol, a xanthohumol derivative, attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARγ. Elife. 2021;10. doi:10.7554/eLife.66398. PubMed: 34128467.

Nash MJ, Dobrinskikh E, Newsom SA, et al. Maternal Western diet exposure increases periportal fibrosis beginning in utero in nonhuman primate offspring. JCI Insight. 2021;6(24). doi:10.1172/jci.insight.154093. PubMed: 34935645.

Newsom SA, Stierwalt HD, Ehrlicher SE, Robinson MM. Substrate-Specific Respiration of Isolated Skeletal Muscle Mitochondria after 1 h of Moderate Cycling in Sedentary Adults. Med Sci Sports Exerc. 2021;53(7):1375-1384. doi:10.1249/MSS.0000000000002615. PubMed: 34127633.

2020

Ehrlicher SE, Stierwalt HD, Miller BF, Newsom SA, Robinson MM. Mitochondrial adaptations to exercise do not require Bcl2-mediated autophagy but occur with BNIP3/Parkin activation. FASEB J. 2020. doi:10.1096/fj.201902594RR. PubMed: 32030805.

Kahn D, Perreault L, Macias E, et al. Subcellular localisation and composition of intramuscular triacylglycerol influence insulin sensitivity in humans. Diabetologia. 2020. doi:10.1007/s00125-020-05315-0. PubMed: 33128577.

Stierwalt HD, Ehrlicher SE, Robinson MM, Newsom SA. Skeletal Muscle ACSL Isoforms Relate to Measures of Fat Metabolism in Humans. Med Sci Sports Exerc. 2020. doi:10.1249/MSS.0000000000002487. PubMed: 32796254.

Boyle KE, Magill-Collins MJ, Newsom SA, Janssen RC, Friedman JE. Maternal Fat-1 Transgene Protects Offspring from Excess Weight Gain, Oxidative Stress, and Reduced Fatty Acid Oxidation in Response to High-Fat Diet. Nutrients. 2020;12(3). doi:10.3390/nu12030767. PubMed: 32183350.

Kia K, Fitch SM, Newsom SA, Kim JH. Effect of whole-body vibration exposures on physiological stresses: Mining heavy equipment applications. Appl Ergon. 2020;85:103065. doi:10.1016/j.apergo.2020.103065. PubMed: 32174353.

Kelahmetoglu Y, Jannig PR, Cervenka I, et al. Comparative Analysis of Skeletal Muscle Transcriptional Signatures Associated With Aerobic Exercise Capacity or Response to Training in Humans and Rats. Front Endocrinol (Lausanne). 2020;11:591476. doi:10.3389/fendo.2020.591476. PubMed: 33193103.

2019

Axton ER, Beaver LM, St Mary L, et al. Treatment with Nitrate, but Not Nitrite, Lowers the Oxygen Cost of Exercise and Decreases Glycolytic Intermediates While Increasing Fatty Acid Metabolites in Exercised Zebrafish. J Nutr. 2019. doi:10.1093/jn/nxz202. PubMed: 31495890.

Stierwalt HD, Ehrlicher SE, Robinson MM, Newsom SA. Diet and Exercise Training Influence Skeletal Muscle Long-Chain acyl-CoA Synthetases. Med Sci Sports Exerc. 2019. doi:10.1249/MSS.0000000000002164. PubMed: 31524824.

Robinson MM, Sather BK, Burney ER, et al. Robust intrinsic differences in mitochondrial respiration and H2O2 emission between L6 and C2C12 cells. American Journal of Physiology-Cell Physiology. 2019;317(2):C339 - C347. doi:10.1152/ajpcell.00343.2018.

Sachs S, Zarini S, Kahn DE, et al. Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans. Am J Physiol Endocrinol Metab. 2019;316(5):E866-E879. doi:10.1152/ajpendo.00243.2018. PubMed: 30620635.

2018

Dasari S, Newsom SA, Ehrlicher SE, Stierwalt HD, Robinson MM. Remodeling of skeletal muscle mitochondrial proteome with high-fat diet involves greater changes to β-oxidation than electron transfer proteins in mice. Am J Physiol Endocrinol Metab. 2018. doi:10.1152/ajpendo.00051.2018. PubMed: 29812987.

Ehrlicher SE, Stierwalt HD, Newsom SA, Robinson MM. Skeletal muscle autophagy remains responsive to hyperinsulinemia and hyperglycemia at higher plasma insulin concentrations in insulin-resistant mice. Physiological Reports. 2018;6(14):e13810. doi:10.14814/phy2.13810.

Stierwalt HD, Ehrlicher SE, Bergman BC, Robinson MM, Newsom SA. Insulin-stimulated Rac1-GTP binding is not impaired by palmitate treatment in L6 myotubes. Physiol Rep. 2018;6(24):e13956. doi:10.14814/phy2.13956. PubMed: 30592185.

Perreault L, Newsom SA, Strauss A, et al. Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle. JCI Insight. 2018;3(3). doi:10.1172/jci.insight.96805. PubMed: 29415895.

Robinson MM, Lowe VJ, K Nair S. Increased Brain Glucose Uptake After 12 Weeks of Aerobic High-Intensity Interval Training in Young and Older Adults. J Clin Endocrinol Metab. 2018;103(1):221-227. doi:10.1210/jc.2017-01571. PubMed: 29077855.