Translational Metabolism Research Laboratory

Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans

In Brief

Robinson et al. assessed the effects of three different exercise modalities on skeletal muscle adaptations in young and older adults. While all enhanced insulin sensitivity, only HIIT and combined training improved aerobic capacity, associated with enhanced translation of mitochondrial proteins. HIIT effectively improved cardio-metabolic health parameters in aging adults.

Highlights

• High-intensity interval training improved age-related decline in muscle mitochondria
• Training adaptations occurred with increased gene transcripts and ribosome proteins
• Changes to RNA with training had little overlap with corresponding protein abundance
• Enhanced ribosomal abundance and protein synthesis explain gains in mitochondria

Media mentions

• New York Times: The Best Exercise for Aging Muscles
• CBC News: 'Get out of your comfort zone:' Interval training benefits extend to aging
• CNN: Interval training exercise could be a fountain of youth
• Optimizing Mitochondrial Production
• Age Stronger: Age Reversal – Doing What’s Difficult.

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