Influence of cocaine use reduction on markers of immune function
This study investigated the impact of reduced cocaine use on immune function among participants with Cocaine Use Disorder in a 12-week trial. The findings indicated that those receiving high-value reinforcers for abstinence showed the most significant reductions in use and notable changes in immune markers, suggesting that reducing cocaine use may enhance immune health.
College of Health researcher(s)
Highlights
- Improved cell-mediated immunity is associated with reduced cocaine use.
- CCL5 and IL-10 decreased in association with reduced cocaine use.
- CRP increased in follow-up in association with reduced cocaine use.
Abstract
This study determined the effects of reduced cocaine use on immune function. Treatment seeking participants with Cocaine Use Disorder enrolled in a 12-week contingency management trial to reduce cocaine use. Participants were randomly assigned 1:1:1 to High Value Reinforcers (i.e., $55/negative urine sample) for cocaine abstinence (n = 41), Low Value Reinforcers (i.e., $13/negative urine sample) for cocaine abstinence (n = 33) or Non-Contingent Control (n = 33). Immune measures were collected at 6-week intervals. The High Value group had greatest use reductions, increased erythema and IL-6 and decreased IL-10 and CCL5, suggesting an activated immune response. Cocaine use reduction may promote changes in immune health.