Can High Pressure Processing (HPP) and Ultraviolet-C Irradiation (UV-C) Treatment Preserve Donor Milk Bioactive Protein Structure and Function Better than Holder Pasteurization?

PIs: Dave Dallas, Adam Higgins (OSU), Joy Waite-Cusic (OSU)

Team members: Ningjian Liang, Hussein Mohamed, Abdul Wazed, Bum Jin Kim, Michael Pitino, Cameron Sugden

Funder: National Institutes of Health

Our long-term goal is to optimize feeding practices for preterm infants to improve their health outcomes. The objectives of this research are to identify the minimum high pressure processing and UV-C treatment conditions that achieve equivalent microbiological safety to Holder pasteurization while optimally preserving bioactive protein structure and function. The positive impact of this research will be guidance for donor milk processors on how to optimally process donor milk for feeding preterm infants and information for clinicians on how to evaluate available donor milk sources. Changes in milk processing to better preserve bioactive milk proteins could improve preterm infant health outcomes.

Effects of Human Milk Handling Practices on Peptide Release and Bioactivity in the Preterm Infant Intestine

PIs: Dave Dallas, Brian Scottoline (Oregon Health & Sciences University), Yimin Chen (University of Idaho), Yanming Di (OSU)

Team members: Abdul Wazed, Bum Jin Kim, Atik Rahman, Rohit Kumar

Funder: National Institutes of Health

Our long-term goal is to determine feeding practices for preterm infants that promote optimal ex utero development and growth. The overall objective of this proposal is to identify how common milk handling practices affect the release of gut health-promoting peptides within the preterm infant intestine. The positive impact of this research is that it will help determine optimal milk handling practices for preterm infants, and provide a pipeline for supplementation strategies for milk that will lead to improved bioactivity within the infant gut.

Can High Pressure Processing of Donor Milk Improve Lipid Absorption and Growth in Preterm Infants Compared with Holder Pasteurization?

PIs: Dave Dallas, Brian Scottoline (OHSU), Yanming Di (OSU)

Funder: Gerber Foundation

Team members: Bum Jin Kim, Caleb Mark, Molly Aloia

Our long-term goal is to optimize feeding practices for preterm infants to improve their health outcomes. Our overall objective is to determine the extent to which HPP-treated milk increases fat digestion and absorption, impacts growth and affects other clinical outcomes in infants compared with Holder pasteurized human donor milk. The positive impact of this research is that it will guide future human milk processing to improve infant health outcomes.

Various projects with industry

Team members

• Brianne Wai
• Bum Jin Kim
• Ningjian Liang

Companies

• Helaina
• Tatua Co-operative Dairy Company
• Bobbie Labs
• Prolacta Biosciences
• Hilmar Ingredients
• Abbott