Can High Pressure Processing (HPP) and Ultraviolet-C Irradiation (UV-C) Treatment Preserve Donor Milk Bioactive Protein Structure and Function Better than Holder Pasteurization?

PIs: Dave Dallas, Adam Higgins (OSU), Joy Waite-Cusic (OSU)

Team members: Ningjian Liang, Hussein Mohamed, Abdul Wazed, Bum Jin Kim, Michael Pitino, Cameron Sugden

Funder: National Institutes of Health

Our long-term goal is to optimize feeding practices for preterm infants to improve their health outcomes. The objectives of this research are to identify the minimum high pressure processing and UV-C treatment conditions that achieve equivalent microbiological safety to Holder pasteurization while optimally preserving bioactive protein structure and function. The positive impact of this research will be guidance for donor milk processors on how to optimally process donor milk for feeding preterm infants and information for clinicians on how to evaluate available donor milk sources. Changes in milk processing to better preserve bioactive milk proteins could improve preterm infant health outcomes.

Can High Pressure Processing of Donor Milk Improve Lipid Absorption and Growth in Preterm Infants Compared with Holder Pasteurization?

PIs: Dave Dallas, Brian Scottoline (OHSU), Yanming Di (OSU)

Funder: Gerber Foundation

Team members: Bum Jin Kim, Caleb Mark, Molly Aloia

Our long-term goal is to optimize feeding practices for preterm infants to improve their health outcomes. Our overall objective is to determine the extent to which HPP-treated milk increases fat digestion and absorption, impacts growth and affects other clinical outcomes in infants compared with Holder pasteurized human donor milk. The positive impact of this research is that it will guide future human milk processing to improve infant health outcomes.

BUILD Dairy Research

Funder

BUILD Dairy with industry partners

Student projects

Russell Kuhfeld

Predicting the Evolution of Cheese Bitterness via Peptidomics, Protease-Focused Proteomics and Microbial Sequencing

Yunyao Qu

Effect of Daily Consumption of Glycomacropeptide on Human Gut Health

Sam Adler

Effect of Whey Consumption and Glycomacropeptide on the Immune System

Suwimon (Noom) Sutantawong

Survival of intact whey proteins and release of bioactive peptides across gastrointestinal digestion in adult consumers

Paige Benson

The effects of different adjunct cultures on bitterness prevention in model cheddar cheese

Marie Biondi

Novel method development for detection of glycomacropeptide fragments in human blood

Joanna Haas

Effects of spray drying and freeze drying on the retention of bioactive proteins in whey

Rudy Sykora

Capacity of high pressure processing to ensure safety while preserving bovine milk bioactive proteins

Bishal Barman

UV-C processing to for microbial reduction and bioactive protein preservation in bovine milk

Various projects with industry

Team members

• Brianne Wai
• Bum Jin Kim
• Ningjian Liang

Companies

• Helaina
• Tatua Co-operative Dairy Company
• Bobbie Labs
• Prolacta Biosciences
• Hilmar Ingredients
• Abbott