TitleVitamins E and C modulate the association between reciprocally regulated cytokines after an anterior cruciate ligament injury and surgery.
Publication TypeJournal Article
Year of Publication2011
AuthorsBarker, T, Martins, TB, Hill, HR, Kjeldsberg, CR, Trawick, RH, Leonard, SW, Walker, JA, Traber, M
JournalAmerican journal of physical medicine & rehabilitation / Association of Academic Physiatrists
Volume90
Issue8
Pagination638-47
Date Published2011 Aug
KeywordsVitamin E
Abstract

OBJECTIVE: : The purpose of this study was to identify the influence of vitamin E and C supplementation on inflammatory cytokines and the association between reciprocally regulated cytokines after anterior cruciate ligament surgery. DESIGN: : A double-blind, placebo-controlled study was conducted in men undergoing anterior cruciate ligament surgery who were randomly assigned to one of two groups (n = 10/group): (1) antioxidant (vitamins E and C) or (2) matching placebos starting ∼2 wks before (baseline) and concluding 3 mos after surgery. Plasma inflammatory cytokines were measured in fasting blood draw samples before and after anterior cruciate ligament surgery. RESULTS: : Plasma interleukin (IL) 1β concentrations were double at 3 mos after surgery compared with baseline. Plasma IL-1β increased to a greater (P < 0.05) extent relative to IL-4 in the placebo group (mean ± SE slope, 18.87 ± 0.68; r = 0.97) than in the antioxidant group (mean ± SE slope, 4.84 ± 0.42; r = 0.89). Similarly, the relative increase in IL-1β to IL-2 was greater (P < 0.05) in the placebo (mean ± SE slope, 2.70 ± 0.21) than in the antioxidant (mean ± SE slope, 1.08 ± 0.23) group. CONCLUSIONS: : Vitamins E and C were ineffective in ameliorating the increases in IL-1β but altered associations between reciprocally regulated cytokines after anterior cruciate ligament surgery.

DOI10.1097/PHM.0b013e318214e886