|Title||Sympathetic responses to repetitive trans-spinal magnetic stimulation.|
|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Paxton, RJ, Malcolm, MP, Newsom, SA, Richards, JC, Rynn, GM, Bell, C|
|Journal||Clin Auton Res|
|Keywords||Adult, Female, Heart Rate, Humans, Magnetic Field Therapy, Male, Muscle, Skeletal, Spinal Cord, Sympathetic Nervous System|
PURPOSE: Electromagnetic fields have been administered, with mixed success, in order to treat a variety of ailments. Transcranial magnetic stimulation (TMS) elicits brief changes in peripheral sympathetic nervous system (SNS) activity. The purpose of this study was to explore the utility of repetitive trans-spinal magnetic stimulation (rTSMS) for acute and prolonged modulation of SNS in adult humans.
METHODS: 23 healthy men and women were randomly assigned to receive either rTSMS (figure-eight coil aligned with the sixth and seventh cervical vertebrae; 10 Hz; n = 14, at 100% intensity of stimulator output) or sham stimulation (n = 13).
RESULTS: Compared with sham, rTSMS did not affect skeletal muscle SNS activity (via microneurography) during the 60-s or 10-min period following stimulation. rTSMS also had no effect on R-to-R interval (RR(int)) and standard deviation of RR(int) (a marker of heart rate variability), blood pressure or plasma concentrations of norepinephrine, epinephrine, insulin and glucose (condition/time interaction, all P > 0.10).
CONCLUSION: These data suggest that rTSMS does not influence SNS in adults. While rTSMS represents a novel application of TMS technology, further study and perhaps modification of the technique is required before use in clinical studies of peripheral SNS function.
|Alternate Journal||Clin. Auton. Res.|
|Grant List||AG022053 / AG / NIA NIH HHS / United States|