|Title||Socioeconomic status as a risk factor for dementia death: individual participant meta-analysis of 86 508 men and women from the UK.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Russ, TC, Stamatakis, E, Hamer, M, Starr, JM, Kivimäki, M, Batty, GD|
|Journal||Br J Psychiatry|
|Date Published||2013 Jul|
|Keywords||Dementia, Educational Status, Female, Health Behavior, Health Surveys, Humans, Male, Prognosis, Risk Factors, Risk-Taking, Smoking, Social Class, Socioeconomic Factors, United Kingdom|
BACKGROUND: Life-course socioeconomic factors may have a role in dementia aetiology but there is a current paucity of studies. Meta-analyses of individual participant data would considerably strengthen this evidence base.
AIMS: To examine the association between socioeconomic status in early life and adulthood with later dementia death.
METHOD: Individual participant meta-analysis of 11 prospective cohort studies (1994-2004, n = 86 508).
RESULTS: Leaving full-time education at an earlier age was associated with an increased risk of dementia death in women (fully adjusted hazard ratio (HR) for age ≤14 v. age ≥16: HR = 1.76, 95% CI 1.23-2.53) but not men. Occupational social class was not statistically significantly associated with dementia death in men or women.
CONCLUSIONS: Lower educational attainment in women was associated with an increased risk of dementia-related death independently of common risk behaviours and comorbidities.
|Alternate Journal||Br J Psychiatry|
|PubMed Central ID||PMC3696876|
|Grant List||RG/13/2/30098 / / British Heart Foundation / United Kingdom |
R01 HL036310 / HL / NHLBI NIH HHS / United States
R01 AG034454 / AG / NIA NIH HHS / United States
MR/K026992/1 / / Medical Research Council / United Kingdom
G0700704 / / Medical Research Council / United Kingdom
R01AG034454 / AG / NIA NIH HHS / United States
R01HL036310 / HL / NHLBI NIH HHS / United States
/ / Wellcome Trust / United Kingdom