TitleSocioeconomic status as a risk factor for dementia death: individual participant meta-analysis of 86 508 men and women from the UK.
Publication TypeJournal Article
Year of Publication2013
AuthorsRuss, TC, Stamatakis, E, Hamer, M, Starr, JM, Kivimäki, M, Batty, GD
JournalBr J Psychiatry
Date Published2013 Jul
KeywordsDementia, Educational Status, Female, Health Behavior, Health Surveys, Humans, Male, Prognosis, Risk Factors, Risk-Taking, Smoking, Social Class, Socioeconomic Factors, United Kingdom

BACKGROUND: Life-course socioeconomic factors may have a role in dementia aetiology but there is a current paucity of studies. Meta-analyses of individual participant data would considerably strengthen this evidence base.

AIMS: To examine the association between socioeconomic status in early life and adulthood with later dementia death.

METHOD: Individual participant meta-analysis of 11 prospective cohort studies (1994-2004, n = 86 508).

RESULTS: Leaving full-time education at an earlier age was associated with an increased risk of dementia death in women (fully adjusted hazard ratio (HR) for age ≤14 v. age ≥16: HR = 1.76, 95% CI 1.23-2.53) but not men. Occupational social class was not statistically significantly associated with dementia death in men or women.

CONCLUSIONS: Lower educational attainment in women was associated with an increased risk of dementia-related death independently of common risk behaviours and comorbidities.

Alternate JournalBr J Psychiatry
PubMed ID23818534
PubMed Central IDPMC3696876
Grant ListRG/13/2/30098 / / British Heart Foundation / United Kingdom
R01 HL036310 / HL / NHLBI NIH HHS / United States
R01 AG034454 / AG / NIA NIH HHS / United States
MR/K026992/1 / / Medical Research Council / United Kingdom
G0700704 / / Medical Research Council / United Kingdom
R01AG034454 / AG / NIA NIH HHS / United States
R01HL036310 / HL / NHLBI NIH HHS / United States
/ / Wellcome Trust / United Kingdom