TitleSkeletal muscle aging and the mitochondrion.
Publication TypeJournal Article
Year of Publication2013
AuthorsJohnson, ML, Robinson, MM, K Nair, S
JournalTrends Endocrinol Metab
Volume24
Issue5
Pagination247-56
Date Published2013 May
ISSN1879-3061
KeywordsAging, Animals, Humans, Mitochondria, Muscle, Mitochondrial Diseases, Mitochondrial Dynamics, Mitochondrial Proteins, Models, Biological, Muscle Proteins, Muscle, Skeletal, Oxidative Stress, Protein Stability, Sarcopenia, Signal Transduction
Abstract

Decline in human muscle mass and strength (sarcopenia) is a hallmark of the aging process. A growing body of research in the areas of bioenergetics and protein turnover has placed the mitochondria at the center of this process. It is now clear that, unless an active lifestyle is rigorously followed, skeletal muscle mitochondrial decline occurs as humans age. Increasing research on mitochondrial biology has elucidated the regulatory pathways involved in mitochondrial biogenesis, many of which are potential therapeutic targets, and highlight the beneficial effects of vigorous physical activity on skeletal muscle health for an aging population.

DOI10.1016/j.tem.2012.12.003
Alternate JournalTrends Endocrinol. Metab.
PubMed ID23375520
PubMed Central IDPMC3641176
Grant ListR01 DK041973 / DK / NIDDK NIH HHS / United States
R01-DK41973 / DK / NIDDK NIH HHS / United States
UL1-RR-024150-01 / RR / NCRR NIH HHS / United States
T32 DK007198 / DK / NIDDK NIH HHS / United States
AG09531 / AG / NIA NIH HHS / United States
T32 DK007352-32 / DK / NIDDK NIH HHS / United States
UL1 TR000135 / TR / NCATS NIH HHS / United States
T32 DK007352 / DK / NIDDK NIH HHS / United States
UL1 RR024150 / RR / NCRR NIH HHS / United States
R01 AG009531 / AG / NIA NIH HHS / United States