Title | Skeletal muscle aging and the mitochondrion. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Johnson, ML, Robinson, MM, K Nair, S |
Journal | Trends Endocrinol Metab |
Volume | 24 |
Issue | 5 |
Pagination | 247-56 |
Date Published | 02/2013 |
ISSN | 1879-3061 |
Keywords | Aging, Animals, Humans, Mitochondria, Muscle, Mitochondrial Diseases, Mitochondrial Dynamics, Mitochondrial Proteins, Models, Biological, Muscle Proteins, Muscle, Skeletal, Oxidative Stress, Protein Stability, Sarcopenia, Signal Transduction |
Abstract | Decline in human muscle mass and strength (sarcopenia) is a hallmark of the aging process. A growing body of research in the areas of bioenergetics and protein turnover has placed the mitochondria at the center of this process. It is now clear that, unless an active lifestyle is rigorously followed, skeletal muscle mitochondrial decline occurs as humans age. Increasing research on mitochondrial biology has elucidated the regulatory pathways involved in mitochondrial biogenesis, many of which are potential therapeutic targets, and highlight the beneficial effects of vigorous physical activity on skeletal muscle health for an aging population. |
DOI | 10.1016/j.tem.2012.12.003 |
Alternate Journal | Trends Endocrinol. Metab. |
PubMed ID | 23375520 |
PubMed Central ID | PMC3641176 |
Grant List | R01 DK041973 / DK / NIDDK NIH HHS / United States R01-DK41973 / DK / NIDDK NIH HHS / United States UL1-RR-024150-01 / RR / NCRR NIH HHS / United States T32 DK007198 / DK / NIDDK NIH HHS / United States AG09531 / AG / NIA NIH HHS / United States T32 DK007352-32 / DK / NIDDK NIH HHS / United States UL1 TR000135 / TR / NCATS NIH HHS / United States T32 DK007352 / DK / NIDDK NIH HHS / United States UL1 RR024150 / RR / NCRR NIH HHS / United States R01 AG009531 / AG / NIA NIH HHS / United States |