|Title||A single session of low-intensity exercise is sufficient to enhance insulin sensitivity into the next day in obese adults.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Newsom, SA, Everett, AC, Hinko, A, Horowitz, JF|
|Keywords||Adult, Blood Glucose, Exercise, Exercise Therapy, Female, Glucose Clamp Technique, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Obesity, Young Adult|
OBJECTIVE: The purpose of this study was to determine the effect of a relatively modest session of exercise on insulin sensitivity and fatty acid uptake the next day in obese adults.
RESEARCH DESIGN AND METHODS: Eleven sedentary obese adults (male/female: 3/8; BMI 37 ± 1 kg/m(2); peak oxygen uptake [VO2peak] 20 ± 1 mL/kg/min) completed three experimental trials. On two of these occasions, subjects exercised to expend 350 kcal in the afternoon. These two exercise trials were identical except for the exercise intensity (50% VO2peak [EX50] and 65% VO2peak [EX65]) and the duration of exercise necessary to expend 350 kcal (EX50 = ≈ 70 min; EX65 = ≈ 55 min). Subjects also completed a control trial (CON), without exercise. The next morning, we measured insulin sensitivity (hyperinsulinemic-euglycemic clamp) and whole-body fatty acid uptake (palmitate rate of disappearance from plasma [Rd]).
RESULTS: Exercise increased insulin sensitivity the next day, but whereas the 35% improvement after EX50 compared with CON was statistically significant (P = 0.01), the 20% improvement after EX65 was not (P = 0.17). Despite nearly identical values between CON and EX65 (P = 0.88), systemic fatty acid uptake was lower after EX50 compared with EX65 (P = 0.02), but not quite significant compared with CON (P = 0.07). Importantly, the change in fatty acid uptake after exercise compared with CON was negatively correlated with the change in insulin sensitivity for all trials (r = -0.60, P = 0.003).
CONCLUSIONS: A relatively modest single session of exercise in obese adults improved insulin sensitivity the next day, and a reduction in systemic fatty acid uptake in the several hours after exercise may be important for this effect.
|Alternate Journal||Diabetes Care|
|PubMed Central ID||PMC3747878|
|Grant List||UL1 TR000433 / TR / NCATS NIH HHS / United States |
P30 DK092926 / DK / NIDDK NIH HHS / United States
R01 DK077966 / DK / NIDDK NIH HHS / United States
R01-DK-077966 / DK / NIDDK NIH HHS / United States
DK-020572 / DK / NIDDK NIH HHS / United States
DK-089503 / DK / NIDDK NIH HHS / United States
P30 DK089503 / DK / NIDDK NIH HHS / United States
P60 DK020572 / DK / NIDDK NIH HHS / United States
P30 DK020572 / DK / NIDDK NIH HHS / United States