|Title||Sarcopenic obesity and risk of new onset depressive symptoms in older adults: English Longitudinal Study of Ageing.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Hamer, M, Batty, GD, Kivimäki, M|
|Journal||Int J Obes (Lond)|
|Keywords||Aged, Aging, Depression, England, Female, Follow-Up Studies, Hand Strength, Humans, Longitudinal Studies, Male, Muscle Strength, Obesity, Odds Ratio, Risk Factors, Sarcopenia, Sex Factors|
BACKGROUND: We examined the role of sarcopenic obesity as a risk factor for new-onset depressive symptoms over 6-year follow-up in a large sample of older adults.
METHODS: The sample comprised 3862 community dwelling participants (1779 men, 2083 women; mean age 64.6±8.3 years) without depressive symptoms at baseline, recruited from the English Longitudinal Study of Ageing. At baseline and 4-year follow-up, handgrip strength (kg) of the dominant hand was assessed using a hand-held dynamometer, as a measure of sarcopenia. The outcome was new onset depressive symptoms at 6-year follow-up, defined as a score of ⩾4 on the 8-item Centre of Epidemiological Studies Depression scale. Sarcopenic obesity was defined as obese individuals (body mass index ⩾30 kg m(-)(2)) in the lowest tertile of sex-specific grip strength (<35.3 kg men; <19.6 kg women).
RESULTS: Using a multivariable logistic regression model, the risk of depressive symptoms was greatest in obese adults in the lowest tertile of handgrip strength (odds ratio (OR), 1.79, 95% confidence interval (CI), 1.10, 2.89) compared with non-obese individuals with high handgrip strength. Participants who were obese at baseline and had a decrease of more than 1 s.d. in grip strength over 4-year follow-up were at greatest risk of depressive symptoms (OR=1.97, 95% CI, 1.22, 3.17) compared with non-obese with stable grip strength.
CONCLUSIONS: A reduction in grip strength was associated with higher risk of depressive symptoms in obese participants only, suggesting that sarcopenic obesity is a risk factor for depressive symptoms.
|Alternate Journal||Int J Obes (Lond)|
|PubMed Central ID||PMC4722238|
|Grant List||RE/10/005/28296 / / British Heart Foundation / United Kingdom |
K013351 / / Medical Research Council / United Kingdom
MR/K026992/1 / / Medical Research Council / United Kingdom
R01 AG017644 / AG / NIA NIH HHS / United States
MR/K013351/1 / / Medical Research Council / United Kingdom
2R01AG7644-01A1 / AG / NIA NIH HHS / United States
2R01AG017644 / AG / NIA NIH HHS / United States