|Title||Resveratrol and Exercise May Improve Kidney Disease Co-morbidities in a Model of Uremia|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Chung, HRyong, Tomayko, EJ, Wu, PT, Cachia, AJ, Cortez, FT, Wilund, KR|
|Journal||Medicine & Science in Sports & Exercise|
PURPOSE: Excessive inflammation and oxidative stress in chronic kidney disease (CKD) promote muscle wasting, and vascular disease. Two therapies that have shown promise in treating these conditionings are resveratrol, which is enriched in polyphenolic compounds with anti-oxidant and anti-inflammatory properties, and exercise, which has been shown to have anti-inflammatory and anti-atherogenic effects. The purpose of this study was to test the efficacy of exercise (EXE) and resveratrol (RSV) on CKD co-morbidities in uremic mice. METHODS: Female ApoE-/- mice (n=24) with surgically-induced uremia were randomly assigned to the following dietary groups for 16 weeks: control diet/sedentary (CON), control diet supplemented with resveratrol at 0.04%/sedentary (RSV), control diet/exercise (EXE). The exercise protocol consisted of treadmill running 45min/day, 5 days/week at 15 m/min. One week before sacrifice, maximal aerobic capacity (VO2max) was assessed by treadmill test to measure physical function. At sacrifice, atherosclerosis (Oil Red O staining) and calcification (Arizarin Red staining) in the proximal aorta were quantified using image analysis software at 3 sites, the coronary cusps, the orifices of the coronary arteries, and the ascending aorta. All statisrical tests used a two-tailed significance alpha =0.05, and independent sample t-tests were used to assess group differences in atherosclerotic lesion size. RESULTS: Aortic atherosclerotic lesion area did not differ between groups at any site, but aortic calcification was significantly reduced in RSV compared to CON in the section of the proximal aorta corresponding to the orifices of the coronary arteries. In addition, VO2max was reduced by 16% in CON (p<0.05) and 29.5% in EXE groups (p<0.05), but did not change in RSV group, suggesting that RSV attenuates uremia-associated decline in maximal aerobic capacity. CONCLUSIONS: These data suggest that RSV and, in part EXE, may be beneficial in the treatment of a cardiovascular disease and physical functions associated with CKD.