TitleResponse to Harri Hemilä, Ph.D., M.D. - "Conclusions about intervention effects should not be based on surrogate end points.
Publication TypeJournal Article
Year of Publication2007
AuthorsBruno, RS, Leonard, SW, Atkinson, J, Montine, TJ, Ramakrishnan, R, Bray, TM, Traber, M
JournalFree radical biology & medicine
Volume42
Issue4
Pagination579-580
Date Published2007 Feb 15
Abstract

We [1] appreciate Dr. Hemilä’s correspondence regarding our investigation that examined oxidative stress and ascorbic acid supplementation on vitamin E pharmacokinetics in nonsmokers and smokers. Dr. Hemilä conveys a timely and important question regarding the use of vitamin E pharmacokinetics as a surrogate biomarker of dietary requirements.
DOI10.1016/j.freeradbiomed.2006.11.034