Title | Response to Harri Hemilä, Ph.D., M.D. - "Conclusions about intervention effects should not be based on surrogate end points. |
Publication Type | Journal Article |
Year of Publication | 2007 |
Authors | Bruno, RS, Leonard, SW, Atkinson, J, Montine, TJ, Ramakrishnan, R, Bray, TM, Traber, M |
Journal | Free radical biology & medicine |
Volume | 42 |
Issue | 4 |
Pagination | 579-580 |
Date Published | 2007 Feb 15 |
Abstract | We [1] appreciate Dr. Hemilä’s correspondence regarding our investigation that examined oxidative stress and ascorbic acid supplementation on vitamin E pharmacokinetics in nonsmokers and smokers. Dr. Hemilä conveys a timely and important question regarding the use of vitamin E pharmacokinetics as a surrogate biomarker of dietary requirements. |
DOI | 10.1016/j.freeradbiomed.2006.11.034 |