TitleRegulation of Dietary Nitrate and Nitrite: Balancing Essential Physiological Roles with Potential Health Risks
Publication TypeBook Chapter
Year of Publication2017
AuthorsHord, NG, Conley, MN
EditorBryan, NS, Loscalzo, J
Book TitleNitrite and Nitrate in Human Health and Disease
Pagination153 - 162
PublisherSpringer International Publishing
ISBN Number978-3-319-46187-8

Human consumption of dietary nitrate and nitrite is controversial. Exposure through processed meats is associated with gastrointestinal cancer risk while consumption of nitrate from plant food sources, the source of over 80 % of human nitrate consumption, is associated with potential cardiovascular benefits. Identifying the physiological contexts in which dietary nitrate and nitrite produce health benefits and risks is necessary for clear guidance regarding dietary consumption of nitrate-containing foods. Development and application of nitrate and nitrite concentrations in national food databases will assist scientists and regulatory agencies in addressing these questions in prospective epidemiological studies.