TitlePsychological distress and risk of peripheral vascular disease, abdominal aortic aneurysm, and heart failure: pooling of sixteen cohort studies.
Publication TypeJournal Article
Year of Publication2014
AuthorsBatty, GD, Russ, TC, Stamatakis, E, Kivimäki, M
JournalAtherosclerosis
Volume236
Issue2
Pagination385-8
Date Published2014 Oct
ISSN1879-1484
KeywordsAdolescent, Adult, Aged, Aged, 80 and over, Aortic Aneurysm, Abdominal, Cardiovascular Diseases, Cause of Death, Cohort Studies, Coronary Disease, Cross-Sectional Studies, Disease Susceptibility, Female, Follow-Up Studies, Heart Failure, Humans, Male, Middle Aged, Peripheral Vascular Diseases, Registries, Risk, Stress, Psychological, Stroke, United Kingdom, Young Adult
Abstract

OBJECTIVES: Examine the little-tested relation of psychological distress with peripheral vascular disease, abdominal aortic aneurysm, and heart failure.

METHODS: Pooling of raw data from 166,631 male and female participants in 16 UK-based cohort studies. Psychological distress was measured using the 12-item General Health Questionnaire. Peripheral vascular disease, abdominal aortic aneurysm, and heart failure events were based on death register linkage.

RESULTS: During a mean follow-up 9.5 years there were 17,368 deaths of which 8625 were cardiovascular disease-related. Relative to the asymptomatic group (0 score), the highly distressed group (score 7-12) experienced an elevated risk of peripheral vascular disease (adjusted hazard ratio; 95% confidence interval: 3.39; 1.97, 5.82) and heart failure (1.76; 1.37, 2.26). Psychological distress was weakly related to the risk of death from abdominal aortic aneurysm. As anticipated, distress was associated with cardiovascular disease, coronary heart disease, and all strokes combined.

CONCLUSIONS: In the present study, we provide new evidence of mental health-related cardiovascular disease presentations.

DOI10.1016/j.atherosclerosis.2014.06.025
Alternate JournalAtherosclerosis
PubMed ID25137648
Grant ListK013351 / / Medical Research Council / United Kingdom
/ / Biotechnology and Biological Sciences Research Council / United Kingdom
MR/K026992/1 / / Medical Research Council / United Kingdom
MR/K013351/1 / / Medical Research Council / United Kingdom
G0700704 / / Medical Research Council / United Kingdom
R01AG034454 / AG / NIA NIH HHS / United States
R01HL036310 / HL / NHLBI NIH HHS / United States
R01AG013196 / AG / NIA NIH HHS / United States