TitleA prospective cohort study of COVID-19 vaccination, SARS-CoV-2 infection, and fertility.
Publication TypeJournal Article
Year of Publication2022
AuthorsWesselink, AK, Hatch, EE, Rothman, KJ, Wang, TR, Willis, MD, Yland, J, Crowe, HM, Geller, RJ, Willis, SK, Perkins, RB, Regan, AK, Levinson, J, Mikkelsen, EM, Wise, LA
JournalAm J Epidemiol
Date Published01/2022

Some reproductive-aged individuals remain unvaccinated against COVID-19 due to concerns about potential adverse effects on fertility. We examined the associations of COVID-19 vaccination and SARS-CoV-2 infection with fertility among couples trying to conceive spontaneously using data from an internet-based preconception cohort study. We enrolled 2,126 self-identified females residing in the U.S. or Canada during December 2020-September 2021 and followed them through November 2021. Participants completed questionnaires every 8 weeks on sociodemographics, lifestyle, medical factors, and partner information. We fit proportional probabilities regression models to estimate associations between self-reported COVID-19 vaccination and SARS-CoV-2 infection in both partners with fecundability, the per-cycle probability of conception, adjusting for potential confounders. COVID-19 vaccination was not appreciably associated with fecundability in either partner (female FR=1.08, 95% CI: 0.95, 1.23; male FR=0.95, 95% CI: 0.83, 1.10). Female SARS-CoV-2 infection was not strongly associated with fecundability (FR=1.07, 95% CI: 0.87, 1.31). Male infection was associated with a transient reduction in fecundability (FR=0.82, 95% CI: 0.47, 1.45 for infection within 60 days; FR=1.16, 95% CI: 0.92, 1.47 for infection >60 days). These findings indicate that male SARS-CoV-2 infection may be associated with a short-term decline in fertility and that COVID-19 vaccination does not impair fertility in either partner.

Alternate JournalAm J Epidemiol
PubMed ID35051292
PubMed Central IDPMC8807200