TitlePointing the FINGER at multimodal dementia prevention.
Publication TypeJournal Article
Year of Publication2015
AuthorsKivimäki, M, Batty, GD, Batty, GD, Singh-Manoux, A
JournalLancet
Volume386
Issue10004
Pagination1626-7
Date Published10/2015
ISSN1474-547X
KeywordsCognition Disorders, Diet, Exercise, Exercise Therapy, Humans, Male, Vascular Diseases
Abstract
 

Findings from observational studies have shown several modifiable risk factors for subsequent cognitive impairment and dementia. Clinical trials are an imperative next step to test cause and effect; however, results from the mostly single intervention studies have been disappointing so far. The FINGER trial,1 in which investigators combined lifestyle advice, management of cardiovascular disease risk, and cognitive training in a multimodal intervention for patients aged 60–77 years, is therefore a welcome addition to the small evidence base.

At 2 years' follow-up, the authors assessed cognitive function across several domains, reporting a 25–150% improvement in the intervention group compared with the general health advice (usual care) control group. In view of the negative findings from previous lifestyle interventions and cognitive training trials to reduce or delay cognitive ageing,2 because cardiovascular disease risk factors in middle age (rather than at old age) are associated with dementia risk,3 and because, by comparison, even the most successful prevention strategies for coronary heart disease, such as lipid-lowering and antihypertensive therapy, reduce disease risk only by 20–50%,45 the positive effects in the FINGER trial seem surprisingly large.

DOI10.1016/S0140-6736(15)00530-9
Alternate JournalLancet
PubMed ID26595629
Grant ListMR/K013351/1 / / Medical Research Council / United Kingdom