TitleIs personality associated with cancer incidence and mortality? An individual-participant meta-analysis of 2156 incident cancer cases among 42,843 men and women.
Publication TypeJournal Article
Year of Publication2014
AuthorsJokela, M, Batty, GD, Hintsa, T, Elovainio, M, Hakulinen, C, Kivimäki, M
JournalBr J Cancer
Volume110
Issue7
Pagination1820-4
Date Published2014 Apr 02
ISSN1532-1827
KeywordsAnxiety Disorders, Australia, Female, Humans, Incidence, Individuality, Longitudinal Studies, Male, Middle Aged, Mortality, Neoplasms, Neuroticism, Personality, Risk Factors, Survival Analysis, Wisconsin
Abstract

BACKGROUND: The putative role of personality in cancer risk has been controversial, and the evidence remains inconclusive.

METHODS: We pooled data from six prospective cohort studies (British Household Panel Survey; Health and Retirement Study; Household, Income, and Labour Dynamics in Australia; Midlife in the United Survey; Wisconsin Longitudinal Study Graduate; and Sibling samples) for an individual-participant meta-analysis to examine whether personality traits of the Five Factor Model (extraversion, neuroticism, agreeableness, conscientiousness, and openness to experience) were associated with the incidence of cancer and cancer mortality in 42,843 cancer-free men and women at baseline (mean age 52.2 years, 55.6% women).

RESULTS: During an average follow-up of 5.4 years, there were 2156 incident cancer cases. In random-effects meta-analysis adjusted for age, sex, and race/ethnicity, none of the personality traits were associated with the incidence of all cancers or any of the six site-specific cancers included in the analysis (lung, colon, breast, prostate, skin, and leukaemia/lymphoma). In the three cohorts with cause-specific mortality data (421 cancer deaths among 21,835 participants), none of the personality traits were associated with cancer mortality.

CONCLUSIONS: These data suggest that personality is not associated with increased risk of incident cancer or cancer-related mortality.

DOI10.1038/bjc.2014.58
Alternate JournalBr. J. Cancer
PubMed ID24504367
PubMed Central IDPMC3974080
Grant ListR01 HL036310 / HL / NHLBI NIH HHS / United States
K013351 / / Medical Research Council / United Kingdom
/ / Biotechnology and Biological Sciences Research Council / United Kingdom
R01 AG034454 / AG / NIA NIH HHS / United States
MR/K026992/1 / / Medical Research Council / United Kingdom
MR/K013351/1 / / Medical Research Council / United Kingdom
R01AG034454 / AG / NIA NIH HHS / United States
R01HL036310 / HL / NHLBI NIH HHS / United States