TitleOxidative Stress and Vitamin E in Anemia
Publication TypeBook Chapter
Year of Publication2022
AuthorsTraber, M, Kamal-Eldin, A
EditorKarakochuk, CD, Zimmermann, MB, Moretti, D, Kraemer, K
Book TitleNutritional Anemia
Pagination205 - 219
PublisherSpringer International Publishing
ISBN Number978-3-031-14520-9

Oxidative stress is a common denominator in the different anemia types. Anemia can result from nutritional deficiencies (e.g., iron deficiency, vitamin B12 deficiency, and vitamin E deficiency), inherited disorders (hemolytic anemia), and/or from infections or exposure to certain toxins and medications (aplastic anemia). Hemolytic anemia, prevalent in inherited diseases such as sickle cell anemia, thalassemia, glucose-6-phosphate dehydrogenase (G6PD) deficiency, and superoxide dismutase (SOD)-2 deficiency, occurs due to destruction of premature or defective RBCs. We also discuss the relationship between malnutrition and vitamin E status, specifically anemia and neurologic abnormalities arising from frank vitamin E deficiency.