TitleOral health in relation to all-cause mortality: the IPC cohort study.
Publication TypeJournal Article
Year of Publication2017
AuthorsAdolph, M, Darnaud, C, Thomas, F, Pannier, B, Danchin, N, Batty, GD, Bouchard, P
JournalSci Rep
Date Published03/2017
KeywordsAdolescent, Adult, Aged, Aged, 80 and over, Cardiovascular Diseases, Dental Plaque, Female, Gingivitis, Humans, Male, Middle Aged, Mouth Diseases, Neoplasms, Oral Health, Proportional Hazards Models

We evaluated the association between oral health and mortality. The study population comprised 76,188 subjects aged 16-89 years at recruitment. The mean follow-up time was 3.4 ± 2.4 years. Subjects with a personal medical history of cancer or cardiovascular disease and death by casualty were excluded from the analysis. A full-mouth clinical examination was performed in order to assess dental plaque, dental calculus and gingival inflammation. The number of teeth and functional masticatory units <5 were recorded. Causes of death were ascertained from death certificates. Mortality risk was evaluated using Cox regression model with propensity score calibrated for each oral exposure. All-cause mortality risk were raised with dental plaque, gingival inflammation, >10 missing teeth and functional masticatory units <5. All-cancer mortality was positively associated with dental plaque and gingival inflammation. Non-cardiovascular and non-cancer mortality were also positively associated with high dental plaque (HR = 3.30, [95% CI: 1.76-6.17]), high gingival inflammation (HR = 2.86, [95% CI: 1.71-4.79]), >10 missing teeth (HR = 2.31, [95% CI: 1.40-3.82]) and functional masticatory units <5 (HR = 2.40 [95% CI 1.55-3.73]). Moreover, when ≥3 oral diseases were cumulated in the model, the risk increased for all-cause mortality (HR = 3.39, [95% CI: 2.51-5.42]), all-cancer mortality (HR = 3.59, [95% CI: 1.23-10.05]) and non-cardiovascular and non-cancer mortality (HR = 4.71, [95% CI: 1.74-12.7]). The present study indicates a postive linear association between oral health and mortality.

Alternate JournalSci Rep
PubMed ID28294149
PubMed Central IDPMC5353629