TitleOral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial.
Publication TypeJournal Article
Year of Publication2013
AuthorsBatty, GD, Li, Q, Huxley, R, Zoungas, S, Taylor, B-A, Neal, B, de Galan, B, Woodward, M, Harrap, S-B, Colagiuri, S, Patel, A, Chalmers, J
Corporate AuthorsVANCE Collaborative group
JournalEur Psychiatry
Date Published2013 Jan
KeywordsAge Factors, Aged, Aged, 80 and over, Cognition, Cognition Disorders, Dementia, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Periodontal Diseases, Prospective Studies, Quality of Life, Risk, Sex Factors, Socioeconomic Factors

OBJECTIVE: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes.

METHODS: A total of 11,140 men and women aged 55-88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up.

RESULTS: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes.

CONCLUSIONS: Tooth loss was associated with an increased risk of both dementia and cognitive decline.

Alternate JournalEur. Psychiatry
PubMed ID21964484
PubMed Central IDPMC4170753
Grant List / / Medical Research Council / United Kingdom
/ / Biotechnology and Biological Sciences Research Council / United Kingdom
MR/K026992/1 / / Medical Research Council / United Kingdom
081021 / / Wellcome Trust / United Kingdom
/ / Chief Scientist Office / United Kingdom