|Title||Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Batty, GD, Li, Q, Huxley, R, Zoungas, S, Taylor, B-A, Neal, B, de Galan, B, Woodward, M, Harrap, S-B, Colagiuri, S, Patel, A, Chalmers, J|
|Corporate Authors||VANCE Collaborative group|
|Date Published||2013 Jan|
|Keywords||Age Factors, Aged, Aged, 80 and over, Cognition, Cognition Disorders, Dementia, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Periodontal Diseases, Prospective Studies, Quality of Life, Risk, Sex Factors, Socioeconomic Factors|
OBJECTIVE: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes.
METHODS: A total of 11,140 men and women aged 55-88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up.
RESULTS: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes.
CONCLUSIONS: Tooth loss was associated with an increased risk of both dementia and cognitive decline.
|Alternate Journal||Eur. Psychiatry|
|PubMed Central ID||PMC4170753|
|Grant List|| / / Medical Research Council / United Kingdom |
/ / Biotechnology and Biological Sciences Research Council / United Kingdom
MR/K026992/1 / / Medical Research Council / United Kingdom
081021 / / Wellcome Trust / United Kingdom
/ / Chief Scientist Office / United Kingdom