TitleOestrogen plus progestin and lung cancer in postmenopausal women (Women's Health Initiative trial): a post-hoc analysis of a randomised controlled trial.
Publication TypeJournal Article
Year of Publication2009
AuthorsChlebowski, RT, Schwartz, AG, Wakelee, H, Anderson, GL, Stefanick, ML, Manson, JAE, Rodabough, RJ, Chien, JW, Wactawski-Wende, J, Gass, M, Kotchen, JMorley, Johnson, KC, O'Sullivan, MJo, Ockene, JK, Chen, C, F Hubbell, A
JournalLancet
Volume374
Issue9697
Pagination1243-51
Date Published2009 Oct 10
KeywordsWomen's Health
Abstract

In the post-intervention period of the Women's Health Initiative (WHI) trial, women assigned to treatment with oestrogen plus progestin had a higher risk of cancer than did those assigned to placebo. Results also suggested that the combined hormone therapy might increase mortality from lung cancer. To assess whether such an association exists, we undertook a post-hoc analysis of lung cancers diagnosed in the trial over the entire follow-up period.