|Title||Occupational solvent exposure and risk of glioma in the INTEROCC study.|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Benke, G, Turner, MC, Fleming, S, Figuerola, J, Kincl, L, Richardson, L, Blettner, M, Hours, M, Krewski, D, McLean, D, Parent, M-E, Sadetzki, S, Schlaefer, K, Schlehofer, B, Siemiatycki, J, Van Tongeren, M, Cardis, E|
|Journal||Br J Cancer|
|Date Published||2017 Sep 14|
BACKGROUND: The aetiology of glioma remains largely unknown. Occupational solvent exposure has been suggested as a putative cause of glioma, but past studies have been inconsistent. We examined the association between a range of solvents and glioma risk within the INTEROCC project, a study of brain tumours and occupational exposures based on data from seven national case-control studies conducted in the framework of the INTERPHONE study. We also investigated associations according to tumour grade.
METHODS: Data from the seven countries were standardised and then combined into one aggregate data set. Pooled odds ratios (ORs) were estimated for adjusted models that included sex, age, country-region of residence and level of educational attainment. Exposures to any solvent or 11 specific solvents or subgroups were assessed using a modified version of the FINJEM job exposure matrix (JEM) specifically developed for the study, called INTEROCC-JEM.
RESULTS: Analysis included 2000 glioma cases and 5565 controls. For glioma and ever/never exposure to any solvent, the OR was 0.91 (95% confidence interval: 0.74-1.11). All ORs were <1.0 for specific solvents/subgroups. There were no increases in risk according to high or low grade of tumour.
CONCLUSIONS: The results of this study show no consistent associations for any solvent exposures overall or by grade of tumour.British Journal of Cancer advance online publication 14 September 2017; doi:10.1038/bjc.2017.285 www.bjcancer.com.
|Alternate Journal||Br. J. Cancer|