TitleThe natural course of healthy obesity over 20 years.
Publication TypeJournal Article
Year of Publication2015
AuthorsBell, JA, Hamer, M, Sabia, S, Singh-Manoux, A, Batty, GD, Kivimäki, M
JournalJ Am Coll Cardiol
Volume65
Issue1
Pagination101-102
Date Published01/2015
ISSN1558-3597
KeywordsAdult, Disease Progression, Female, Health Status, Humans, Male, Middle Aged, Obesity, Risk Factors
Abstract
 

Intense interest surrounds the “healthy” obese phenotype, which is defined as obesity in the absence of metabolic risk factor clustering (1). Efforts to understand the cardiovascular consequences of healthy obesity are ongoing (2); however, its conceptual validity and clinical value rest onthe assumption that it is a stable physiological state, rather than a transient phase of obesity-associated metabolic deterioration. Therefore, a fundamental question is whether healthy obese adults maintain this metabolically healthy profile over the long term or naturally transition into unhealthy obesity over time. Few studies have examined this; in those that have, durations of follow-up have been modest, with none exceeding 10 years 34. Accordingly, we aimed to describe the natural course of healthy obesity over 2 decades in a large population-based study.

DOI10.1016/j.jacc.2014.09.077
Alternate JournalJ. Am. Coll. Cardiol.
PubMed ID25572516
Grant ListRE/10/005/28296 / / British Heart Foundation / United Kingdom
RG/13/2/30098 / / British Heart Foundation / United Kingdom
K013351 / / Medical Research Council / United Kingdom
MR/K013351/1 / / Medical Research Council / United Kingdom
PG/11/63/29011 / / British Heart Foundation / United Kingdom
R01HL36310 / HL / NHLBI NIH HHS / United States
R01AG034454 / AG / NIA NIH HHS / United States
R01AG013196 / AG / NIA NIH HHS / United States