TitleModifiable cardiovascular disease risk factors as predictors of dementia death: pooling of ten general population-based cohort studies.
Publication TypeJournal Article
Year of Publication2014
AuthorsBatty, GD, Russ, TC, Starr, JM, Stamatakis, E, Kivimäki, M
JournalJ Negat Results Biomed
Date Published2014 May 23
KeywordsCardiovascular Diseases, Cohort Studies, Dementia, Diabetes Complications, Female, Humans, Hypertension, Male, Motor Activity, Prospective Studies, Risk Factors, Smoking

BACKGROUND: With drug treatment for dementia being of limited effectiveness, the role of primary prevention, in particular the predictive value of modifiable cardiovascular disease risk factors, may warrant exploration. The evidence base is, however, characterised by discordant findings and is modest in size. Accordingly, we examined the association of modifiable cardiovascular disease risk factors with dementia death.

DESIGN AND METHODS: We pooled raw data from 10 UK general population-based prospective cohort studies within the context of an individual participant meta-analysis.

RESULTS: A total of 103,764 men and women were followed up for a mean of 8 years giving rise to 443 dementia-related deaths and 2612 cardiovascular disease deaths. Cardiovascular disease mortality was, as anticipated, associated with the full range of risk factors under study, including raised blood pressure, smoking, diabetes, physical inactivity. By contrast, dementia death was related to very few of the cardiovascular disease risk factors: of those classified as modifiable, only smoking was associated with a raised risk and higher levels of non-HDL with a lower risk.

CONCLUSIONS: In the present individual participant meta-analysis, there was limited evidence that cardiovascular disease risk factors were related to dementia death.

Alternate JournalJ Negat Results Biomed
PubMed ID24886432
PubMed Central IDPMC4036694
Grant ListK013351 / / Medical Research Council / United Kingdom
/ / Biotechnology and Biological Sciences Research Council / United Kingdom
MR/K026992/1 / / Medical Research Council / United Kingdom
MR/K013351/1 / / Medical Research Council / United Kingdom
R01 AG034454 / AG / NIA NIH HHS / United States
R01HL036310 / HL / NHLBI NIH HHS / United States
R01AG013196 / AG / NIA NIH HHS / United States