TitleMetabolism and excretion rates of parent and hydroxy-PAHs in urine collected after consumption of traditionally smoked salmon for Native American volunteers.
Publication TypeJournal Article
Year of Publication2015
AuthorsMotorykin, ii, O, Santiago-Delgado, L, Rohlman, D, Schrlau, JE, Harper, B, Harris, S, Harding, A, Kile, ML, Simonich, SLMassey
JournalSci Total Environ
Date Published05/2015
KeywordsAdult, Animals, Biomarkers, Environmental Exposure, Female, Food Contamination, Humans, Indians, North American, Male, Parents, Polycyclic Aromatic Hydrocarbons, Salmon, Volunteers, Water Pollutants, Chemical

Few studies have been published on the excretion rates of parent polycyclic aromatic hydrocarbons (PAHs) and hydroxy-polycyclic aromatic hydrocarbons (OH-PAHs) following oral exposure. This study investigated the metabolism and excretion rates of 4 parent PAHs and 10 OH-PAHs after the consumption of smoked salmon. Nine members of the Confederated Tribes of the Umatilla Indian Reservation consumed 50 g of traditionally smoked salmon with breakfast and five urine samples were collected during the following 24 h. The concentrations of OH-PAHs increased from 43.9 μg/g creatinine for 2-OH-Nap to 349 ng/g creatinine for 1-OH-Pyr, 3 to 6 h post-consumption. Despite volunteers following a restricted diet, there appeared to be a secondary source of naphthalene and fluorene, which led to excretion efficiencies greater than 100%. For the parent PAHs that were detected in urine, the excretion efficiencies ranged from 13% for phenanthrene (and its metabolite) to 240% for naphthalene (and its metabolites). The half-lives for PAHs ranged from 1.4 h for retene to 3.3h for pyrene. The half-lives for OH-PAHs were higher and ranged from 1.7 h for 9-OH-fluorene to 7.0 h for 3-OH-fluorene. The concentrations of most parent PAHs, and their metabolites, returned to the background levels 24 h post-consumption.

Alternate JournalSci. Total Environ.
PubMed ID25659315
PubMed Central IDPMC4361301
Grant ListP30 ES000210 / ES / NIEHS NIH HHS / United States
P42 ES016465 / ES / NIEHS NIH HHS / United States
T32 ES007060 / ES / NIEHS NIH HHS / United States
P30ES00210 / ES / NIEHS NIH HHS / United States