TitleMetabolic Coupling Between Bone Marrow Adipose Tissue and Hematopoiesis.
Publication TypeJournal Article
Year of Publication2018
AuthorsTurner, RT, Martin, SA, Iwaniec, UT
JournalCurr Osteoporos Rep
Volume16
Issue2
Pagination95-104
Date Published04/2018
ISSN1544-2241
Abstract
 

PURPOSE OF REVIEW: Mesenchymal stem cells (MSCs) located in the bone marrow have the capacity to differentiate into multiple cell lineages, including osteoblast and adipocyte. Adipocyte density within marrow is inversely associated with bone mass during aging and in some pathological conditions, contributing to the prevailing view that marrow adipocytes play a largely negative role in bone metabolism. However, a negative association between marrow adipocytes and bone balance is not universal. Although MAT levels appear tightly regulated, establishing the precise physiological significance of MAT has proven elusive. Here, we review recent literature aimed at delineating the function of MAT.

RECENT FINDINGS: An important physiological function of MAT may be to provide an expandable/contractible fat depot, which is critical for minimization of energy requirements for sustaining optimal hematopoiesis. Because the energy requirements for storing fat are negligible compared to those required to maintain hematopoiesis, even small reductions in hematopoietic tissue volume to match a reduced requirement for hematopoiesis could represent an important reduction in energy cost. Such a physiological function would require tight coupling between hematopoietic stem cells and MSCs to regulate the balance between MAT and hematopoiesis. Kit-ligand, an important regulator of proliferation, differentiation, and survival of hematopoietic cells, may function as a prototypic factor coupling MAT and hematopoiesis. Crosstalk between hematopoietic and mesenchymal cells in the bone marrow may contribute to establishing the balance between MAT levels and hematopoiesis.

DOI10.1007/s11914-018-0422-3
Alternate JournalCurr Osteoporos Rep
PubMed ID29492879
PubMed Central IDPMC5989569
Grant ListR01 AR060913 / AR / NIAMS NIH HHS / United States
R21 AR066811 / AR / NIAMS NIH HHS / United States