TitleMental disorders across the adult life course and future coronary heart disease: evidence for general susceptibility.
Publication TypeJournal Article
Year of Publication2014
AuthorsGale, CR, Batty, GD, Osborn, DPJ, Tynelius, P, Rasmussen, F
JournalCirculation
Volume129
Issue2
Pagination186-93
Date Published2014 Jan 14
ISSN1524-4539
KeywordsAdolescent, Adult, Alcohol Drinking, Body Mass Index, Coronary Disease, Disease Susceptibility, Educational Status, Follow-Up Studies, Humans, Longitudinal Studies, Male, Mental Disorders, Mental Health, Proportional Hazards Models, Registries, Retrospective Studies, Risk Factors, Smoking, Social Class, Sweden, Young Adult
Abstract

BACKGROUND: Depression, anxiety, and psychotic disorders have been associated with an increased risk of coronary heart disease (CHD). It is unclear whether this association between mental health and CHD is present across a wider range of mental disorders.

METHODS AND RESULTS: Participants were 1 107 524 Swedish men conscripted at a mean age of 18.3 years. Mental disorders were assessed by psychiatric interview on conscription, and data on hospital admissions for mental disorder and CHD were obtained from national registers during 22.6 years of follow-up. An increased risk of incident CHD was evident across a range of mental disorders whether diagnosed at conscription or on later hospital admission. Age-adjusted hazard ratios (95% confidence intervals) according to diagnoses at conscription ranged from 1.30 (1.05, 1.62) (depressive disorders) to 1.90 (1.58, 2.38) (alcohol-related disorders). [corrected]. The equivalent figures according to diagnoses during hospital admission ranged from 1.49 (1.24-1.80) (schizophrenia) to 2.82 (2.53-3.13) (other substance use disorders). Associations were little changed by adjustment for parental socioeconomic status, or body mass index, diabetes mellitus, and blood pressure measured at conscription, but they were partially attenuated by the adjustment for smoking, alcohol intake, and intelligence measured at conscription, and for education and own socioeconomic position.

CONCLUSIONS: Increased risk of incident CHD is present across a range of mental disorders and is observable when the disorders are diagnosed at a young age.

DOI10.1161/CIRCULATIONAHA.113.002065
Alternate JournalCirculation
PubMed ID24190959
PubMed Central IDPMC4107269
Grant ListMC_UP_A620_1015 / / Medical Research Council / United Kingdom
MC_U147585827 / / Medical Research Council / United Kingdom
MC_UU_12011/2 / / Medical Research Council / United Kingdom
/ / Medical Research Council / United Kingdom
MC_UP_A620_1015 / / Department of Health / United Kingdom
/ / Biotechnology and Biological Sciences Research Council / United Kingdom
MC_U147585819 / / Medical Research Council / United Kingdom
MR/K026992/1 / / Medical Research Council / United Kingdom
MC_UP_A620_1014 / / Medical Research Council / United Kingdom
MC_UU_12011/1 / / Medical Research Council / United Kingdom
G0400491 / / Medical Research Council / United Kingdom
MC_U147585824 / / Medical Research Council / United Kingdom