TitleLong working hours and depressive symptoms: systematic review and meta-analysis of published studies and unpublished individual participant data.
Publication TypeJournal Article
Year of Publication2018
AuthorsVirtanen, M, Jokela, M, Madsen, IEh, Hanson, LLMagnusso, Lallukka, T, Nyberg, ST, Alfredsson, L, Batty, GD, Bjorner, JB, Borritz, M, Burr, H, Dragano, N, Erbel, R, Ferrie, JE, Heikkilä, K, Knutsson, A, Koskenvuo, M, Lahelma, E, Nielsen, ML, Oksanen, T, Pejtersen, JH, Pentti, J, Rahkonen, O, Rugulies, R, Salo, P, Schupp, J, Shipley, MJ, Siegrist, J, Singh-Manoux, A, Suominen, SB, Theorell, T, Vahtera, J, Wagner, GG, Wang, JLi, Yiengprugsawan, V, Westerlund, H, Kivimäki, M
JournalScand J Work Environ Health
Date Published05/2018
KeywordsAsia, Depression, Europe, Female, Humans, Male, North America, Observational Studies as Topic, Prospective Studies, Risk Assessment, Work Schedule Tolerance

Objectives This systematic review and meta-analysis combined published study-level data and unpublished individual-participant data with the aim of quantifying the relation between long working hours and the onset of depressive symptoms. Methods We searched PubMed and Embase for published prospective cohort studies and included available cohorts with unpublished individual-participant data. We used a random-effects meta-analysis to calculate summary estimates across studies. Results We identified ten published cohort studies and included unpublished individual-participant data from 18 studies. In the majority of cohorts, long working hours was defined as working ≥55 hours per week. In multivariable-adjusted meta-analyses of 189 729 participants from 35 countries [96 275 men, 93 454 women, follow-up ranging from 1-5 years, 21 747 new-onset cases), there was an overall association of 1.14 (95% confidence interval (CI) 1.03-1.25] between long working hours and the onset of depressive symptoms, with significant evidence of heterogeneity (I =45.1%, P=0.004). A moderate association between working hours and depressive symptoms was found in Asian countries (1.50, 95% CI 1.13-2.01), a weaker association in Europe (1.11, 95% CI 1.00-1.22), and no association in North America (0.97, 95% CI 0.70-1.34) or Australia (0.95, 95% CI 0.70-1.29). Differences by other characteristics were small. Conclusions This observational evidence suggests a moderate association between long working hours and onset of depressive symptoms in Asia and a small association in Europe.

Alternate JournalScand J Work Environ Health
PubMed ID29423526
Grant ListMR/K013351/1 / / Medical Research Council / United Kingdom