TitleLong working hours and cancer risk: a multi-cohort study.
Publication TypeJournal Article
Year of Publication2016
AuthorsHeikkilä, K, Nyberg, ST, Madsen, IEH, de Vroome, E, Alfredsson, L, Bjorner, JJ, Borritz, M, Burr, H, Erbel, R, Ferrie, JE, Fransson, EI, Geuskens, GA, Hooftman, WE, Houtman, IL, Jöckel, K-H, Knutsson, A, Koskenvuo, M, Lunau, T, Nielsen, ML, Nordin, M, Oksanen, T, Pejtersen, JH, Pentti, J, Shipley, MJ, Steptoe, A, Suominen, SB, Theorell, T, Vahtera, J, Westerholm, PJM, Westerlund, H, Dragano, N, Rugulies, R, Kawachi, I, Batty, GD, Singh-Manoux, A, Virtanen, M, Kivimäki, M
Corporate AuthorsIPD-Work Consortium
JournalBr J Cancer
Volume114
Issue7
Pagination813-8
Date Published03/2016
ISSN1532-1827
KeywordsAdolescent, Adult, Aged, Female, Follow-Up Studies, Humans, Life Style, Male, Middle Aged, Neoplasms, Prognosis, Prospective Studies, Risk Factors, Socioeconomic Factors, Time Factors, Work Schedule Tolerance, Young Adult
Abstract
 

BACKGROUND: Working longer than the maximum recommended hours is associated with an increased risk of cardiovascular disease, but the relationship of excess working hours with incident cancer is unclear.

METHODS: This multi-cohort study examined the association between working hours and cancer risk in 116 462 men and women who were free of cancer at baseline. Incident cancers were ascertained from national cancer, hospitalisation and death registers; weekly working hours were self-reported.

RESULTS: During median follow-up of 10.8 years, 4371 participants developed cancer (n colorectal cancer: 393; n lung cancer: 247; n breast cancer: 833; and n prostate cancer: 534). We found no clear evidence for an association between working hours and the overall cancer risk. Working hours were also unrelated the risk of incident colorectal, lung or prostate cancers. Working ⩾55 h per week was associated with 1.60-fold (95% confidence interval 1.12-2.29) increase in female breast cancer risk independently of age, socioeconomic position, shift- and night-time work and lifestyle factors, but this observation may have been influenced by residual confounding from parity.

CONCLUSIONS: Our findings suggest that working long hours is unrelated to the overall cancer risk or the risk of lung, colorectal or prostate cancers. The observed association with breast cancer would warrant further research.

DOI10.1038/bjc.2016.9
Alternate JournalBr. J. Cancer
PubMed ID26889978
PubMed Central IDPMC4984872
Grant ListG0100222 / / Medical Research Council / United Kingdom
K013351 / / Medical Research Council / United Kingdom
MR/K026992/1 / / Medical Research Council / United Kingdom
MR/K013351/1 / / Medical Research Council / United Kingdom
R01AG034454 / AG / NIA NIH HHS / United States
R01HL036310 / HL / NHLBI NIH HHS / United States