TitleLong-term variability of inflammatory markers and associated factors in a population-based cohort.
Publication TypeJournal Article
Year of Publication2013
AuthorsNash, SD, Cruickshanks, KJ, Klein, R, Klein, BEK, F. Nieto, J, Chappell, R, Schubert, CR, Tsai, MY
JournalJ Am Geriatr Soc
Volume61
Issue8
Pagination1269-76
Date Published2013 Aug
ISSN1532-5415
KeywordsAdult, Aged, C-Reactive Protein, Cohort Studies, Cross-Sectional Studies, Female, Hearing Loss, Humans, Inflammation, Inflammation Mediators, Interleukin-6, Longitudinal Studies, Male, Middle Aged, Population Surveillance, Prospective Studies, Risk Factors
Abstract
 

OBJECTIVES: To investigate long-term variability in serum high-sensitivity C-reactive protein (CRP) and interleukin-6 (IL-6) and to determine associated risk factors for high-risk inflammatory profiles.

DESIGN: Prospective population-based cohort study.

PARTICIPANTS: Participants (N = 1,443) of the Epidemiology of Hearing Loss Study and the Beaver Dam Eye Study, two population-based prospective studies of aging in the same cohort.

MEASUREMENTS: In participants aged 43 to 79 at the initial examination (1988-1990), serum high-sensitivity CRP was measured from three time-points (1988-1990, 1998-2000, 2009-2010), and serum IL-6 was measured from two (1998-2000, 2009-2010).

RESULTS: When IL-6 levels were categorized into tertiles, 50.8% of participants were in the same group 10 years later (weighted kappa (κ) = 0.34). When CRP was categorized into three risk groups, 53.4% of participants were in the same group 10 years later (κ = 0.36), and 32.4% were in the same group at all three examinations (κ = 0.27). IL-6 increased from a geometric mean of 1.54 pg/L to 1.78 pg/L over 10 years, whereas CRP increased from a geometric mean of 1.67 mg/L to 2.25 mg/L over 10 years and then decreased to 1.93 mg/L over the next 10 years. These 10-year decreases in CRP were not observed in those not reporting statin use. Factors associated with long-term higher levels of IL-6 and CRP were older age (IL-6), obesity, smoking, lower physical activity (IL-6), lower high-density lipoprotein cholesterol (IL-6), and a history of statin (non)use (CRP).

CONCLUSION: Inflammatory marker levels tracked over the long term into older age with within-person increases were observed. Several potentially modifiable risk factors were associated with long-term higher levels of inflammatory markers.

DOI10.1111/jgs.12382
Alternate JournalJ Am Geriatr Soc
PubMed ID23889670
PubMed Central IDPMC3743937
Grant ListU10 EY006594 / EY / NEI NIH HHS / United States
R01 AG011099 / AG / NIA NIH HHS / United States
R37 AG011099 / AG / NIA NIH HHS / United States
DK73217 / DK / NIDDK NIH HHS / United States
R01 DK073217 / DK / NIDDK NIH HHS / United States
U10EY06594 / EY / NEI NIH HHS / United States
R37AG011099 / AG / NIA NIH HHS / United States