|Title||INTEROCC case-control study: lack of association between glioma tumors and occupational exposure to selected combustion products, dusts and other chemical agents.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Lacourt, A, Cardis, E, Pintos, J, Richardson, L, Kincl, L, Benke, G, Fleming, S, Hours, M, Krewski, D, McLean, D, Parent, M-E, Sadetzki, S, Schlaefer, K, Schlehofer, B, Lavoué, J, Van Tongeren, M, Siemiatycki, J|
|Journal||BMC Public Health|
|Keywords||Adult, Aged, Brain Neoplasms, Case-Control Studies, Female, Glioma, Humans, Male, Middle Aged, Occupational Exposure, Risk Factors, Surveys and Questionnaires|
BACKGROUND: The aim was to investigate possible associations between glioma (an aggressive type of brain cancer) and occupational exposure to selected agents: combustion products (diesel and gasoline exhaust emissions, benzo(a)pyrene), dusts (animal dust, asbestos, crystalline silica, wood dust) and some other chemical agents (formaldehyde, oil mist, sulphur dioxide).
METHODS: The INTEROCC study included cases diagnosed with glioma during 2000-2004 in sub-regions of seven countries. Population controls, selected from various sampling frames in different centers, were frequency or individually matched to cases by sex, age and center. Face-to-face interviews with the subject or a proxy respondent were conducted by trained interviewers. Detailed information was collected on socio-economic and lifestyle characteristics, medical history and work history. Occupational exposure to the 10 selected agents was assessed by a job exposure matrix (JEM) which provides estimates of the probability and level of exposure for different occupations. Using a 25% probability of exposure in a given occupation in the JEM as the threshold for considering a worker exposed, the lifetime prevalence of exposure varied from about 1% to about 15% for the different agents. Associations between glioma and each of the 10 agents were estimated by conditional logistic regression, and using three separate exposure indices: i) ever vs. never; ii) lifetime cumulative exposure; iii) total duration of exposure.
RESULTS: The study sample consisted of 1,800 glioma cases and 5,160 controls. Most odds ratio estimates were close to the null value. None of the ten agents displayed a significantly increased odds ratio nor any indication of dose-response relationships with cumulative exposure or with duration of exposure.
CONCLUSION: Thus, there was no evidence that these exposures influence risk of glioma.
|Alternate Journal||BMC Public Health|
|PubMed Central ID||PMC3637633|
|Grant List||1R01CA124759-01 / CA / NCI NIH HHS / United States |
MOP-42525 / / Canadian Institutes of Health Research / Canada
/ / Department of Health / United Kingdom