TitleThe interactions of some commonly consumed drugs with mitochondrial adaptations to exercise.
Publication TypeJournal Article
Year of Publication2009
AuthorsRobinson, MM, Hamilton, KL, Miller, BF
JournalJ Appl Physiol (1985)
Date Published2009 Jul
KeywordsAdaptation, Physiological, Adrenergic beta-Antagonists, Anti-Inflammatory Agents, Non-Steroidal, Drug Interactions, Drug-Related Side Effects and Adverse Reactions, Exercise, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Mitochondria, Muscle, Mitochondrial Diseases

The importance of mitochondrial dysfunctions in the progression of chronic disease has been well established. Patients with chronic diseases are often prescribed a variety of medications, many of which have been shown to induce mitochondrial dysfunction. Exercise is a known stimulus for mitochondrial biogenesis and also recommended to patients as a lifestyle modification to supplement drug therapy. However, the potential interference of those drugs with mitochondrial adaptations to exercise has not been thoroughly investigated. This review provides a summary and discussion of known and potential interactions of commonly consumed drugs with exercise-induced mitochondrial adaptations.

Alternate JournalJ. Appl. Physiol.
PubMed ID19423832