OREGON STATE UNIVERSITY
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| Title | The interactions of some commonly consumed drugs with mitochondrial adaptations to exercise. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Robinson, MM, Hamilton, KL, Miller, BF |
| Journal | J Appl Physiol (1985) |
| Volume | 107 |
| Issue | 1 |
| Pagination | 8-16 |
| Date Published | 2009 Jul |
| ISSN | 8750-7587 |
| Keywords | Adaptation, Physiological, Adrenergic beta-Antagonists, Anti-Inflammatory Agents, Non-Steroidal, Drug Interactions, Drug-Related Side Effects and Adverse Reactions, Exercise, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Mitochondria, Muscle, Mitochondrial Diseases |
| Abstract | The importance of mitochondrial dysfunctions in the progression of chronic disease has been well established. Patients with chronic diseases are often prescribed a variety of medications, many of which have been shown to induce mitochondrial dysfunction. Exercise is a known stimulus for mitochondrial biogenesis and also recommended to patients as a lifestyle modification to supplement drug therapy. However, the potential interference of those drugs with mitochondrial adaptations to exercise has not been thoroughly investigated. This review provides a summary and discussion of known and potential interactions of commonly consumed drugs with exercise-induced mitochondrial adaptations. |
| DOI | 10.1152/japplphysiol.00343.2009 |
| Alternate Journal | J. Appl. Physiol. |
| PubMed ID | 19423832 |