Title | The interactions of some commonly consumed drugs with mitochondrial adaptations to exercise. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Robinson, MM, Hamilton, KL, Miller, BF |
Journal | J Appl Physiol (1985) |
Volume | 107 |
Issue | 1 |
Pagination | 8-16 |
Date Published | 2009 Jul |
ISSN | 8750-7587 |
Keywords | Adaptation, Physiological, Adrenergic beta-Antagonists, Anti-Inflammatory Agents, Non-Steroidal, Drug Interactions, Drug-Related Side Effects and Adverse Reactions, Exercise, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Mitochondria, Muscle, Mitochondrial Diseases |
Abstract | The importance of mitochondrial dysfunctions in the progression of chronic disease has been well established. Patients with chronic diseases are often prescribed a variety of medications, many of which have been shown to induce mitochondrial dysfunction. Exercise is a known stimulus for mitochondrial biogenesis and also recommended to patients as a lifestyle modification to supplement drug therapy. However, the potential interference of those drugs with mitochondrial adaptations to exercise has not been thoroughly investigated. This review provides a summary and discussion of known and potential interactions of commonly consumed drugs with exercise-induced mitochondrial adaptations. |
DOI | 10.1152/japplphysiol.00343.2009 |
Alternate Journal | J. Appl. Physiol. |
PubMed ID | 19423832 |