|Title||Inhibition of cytokine signaling in human retinal endothelial cells through modification of caveolae/lipid rafts by docosahexaenoic acid.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Chen, W, Jump, DB, Esselman, WJ, Busik, JV|
|Journal||Investigative ophthalmology & visual science|
|Date Published||2007 Jan|
Docosahexaenoic acid (DHA(22:6,n3)) is the principal n3 polyunsaturated fatty acid (PUFA) in the retina. The authors previously demonstrated that DHA(22:6,n3) inhibited cytokine-induced adhesion molecule expression in primary human retinal vascular endothelial (hRVE) cells, the target tissue affected by diabetic retinopathy. Despite the importance of vascular inflammation in diabetic retinopathy, the mechanisms underlying anti-inflammatory effects of DHA(22:6,n3) in vascular endothelial cells are not understood. In this study the authors address the hypothesis that DHA(22:6,n3) acts through modifying lipid composition of caveolae/lipid rafts, thereby changing the outcome of important signaling events in these specialized plasma membrane microdomains.