TitleHeight in relation to dementia death: individual participant meta-analysis of 18 UK prospective cohort studies.
Publication TypeJournal Article
Year of Publication2014
AuthorsRuss, TC, Kivimäki, M, Starr, JM, Stamatakis, E, Batty, GD
JournalBr J Psychiatry
Volume205
Issue5
Pagination348-54
Date Published2014 Nov
ISSN1472-1465
KeywordsBody Height, Dementia, Humans, Risk Factors, United Kingdom
Abstract

BACKGROUND: That risk factors measured in middle age may not fully explain future dementia risk implicates exposures acting earlier in life. Height may capture early-life illness, adversity, nutrition and psychosocial stress.

AIMS: To investigate the little-explored association between height and dementia death. Method Individual participant meta-analysis using 18 prospective general population cohort studies with identical methodologies (1994-2008; n = 181 800).

RESULTS: Mean follow-up of 9.8 years gave rise to 426 and 667 dementia deaths in men and women respectively. The mean heights were 174.4 cm (s.d. = 7.3) for men and 161.0 cm (s.d. = 6.8) for women. In analyses taking into account multiple covariates, increasing height was related to lower rates of death from dementia in a dose-response pattern (P ⩽ 0.01 for trend). There was evidence of a differential effect by gender (P = 0.016 for interaction). Thus, the association observed in men (hazard ratio per s.d. decrease in height 1.24, 95% CI 1.11-1.39) was markedly stronger than that apparent in women (HR = 1.13, 95% CI 1.03-1.24).

CONCLUSIONS: Early-life circumstances, indexed by adult height, may influence later dementia risk.

DOI10.1192/bjp.bp.113.142984
Alternate JournalBr J Psychiatry
PubMed ID25368359
PubMed Central IDPMC4217025
Grant ListR01 HL036310 / HL / NHLBI NIH HHS / United States
K013351 / / Medical Research Council / United Kingdom
/ / Biotechnology and Biological Sciences Research Council / United Kingdom
R01 AG034454 / AG / NIA NIH HHS / United States
MR/K026992/1 / / Medical Research Council / United Kingdom
MR/K013351/1 / / Medical Research Council / United Kingdom
R01AG034454 / AG / NIA NIH HHS / United States
R01HL036310 / HL / NHLBI NIH HHS / United States