TitleGenetic studies of fetal hemoglobin in the Arab-Indian haplotype sickle cell-β(0) thalassemia.
Publication TypeJournal Article
Year of Publication2013
AuthorsAlsultan, A, Ngo, D, Bae, H, Sebastiani, P, Baldwin, CT, Melista, E, Suliman, AM, Albuali, WH, Nasserullah, Z, Luo, H-yuan, Chui, DHK, Steinberg, MH, Al-Ali, AK
JournalAmerican journal of hematology
Volume88
Issue6
Pagination531-2
Date Published06/2013
KeywordsPolymorphism, Single Nucleotide
Abstract

Independently of its African roots, the HbS gene is also indigenous to the Middle East and India where it can be on an Arab-Indian (AI) HBB haplotype. This haplotype is associated with high levels of fetal hemoglobin (HbF) and increased HbF improves many complications of sickle cell disease. 1 Polymorphisms in BCL11A (chr 2p) and HBS1L-MYB (chr 6q) and in elements linked to HBB (chr 11p) are associated with HbF level. In AI haplotype HbS homozygotes, SNPs in BCL11A and HBS1L-MYB accounted for 8.8% of HbF variance.
DOI10.1002/ajh.23434