TitleGenetic studies of fetal hemoglobin in the Arab-Indian haplotype sickle cell-β(0) thalassemia.
Publication TypeJournal Article
Year of Publication2013
AuthorsAlsultan, A, Ngo, D, Bae, H, Sebastiani, P, Baldwin, CT, Melista, E, Suliman, AM, Albuali, WH, Nasserullah, Z, Luo, H-yuan, Chui, DHK, Steinberg, MH, Al-Ali, AK
JournalAmerican journal of hematology
Volume88
Issue6
Pagination531-2
Date Published2013 Jun
KeywordsPolymorphism, Single Nucleotide
Abstract

Independently of its African roots, the HbS gene is also indigenous to the Middle East and India where it can be on an Arab-Indian (AI) HBB haplotype. This haplotype is associated with high levels of fetal hemoglobin (HbF) and increased HbF improves many complications of sickle cell disease. 1 Polymorphisms in BCL11A (chr 2p) and HBS1L-MYB (chr 6q) and in elements linked to HBB (chr 11p) are associated with HbF level. In AI haplotype HbS homozygotes, SNPs in BCL11A and HBS1L-MYB accounted for 8.8% of HbF variance.

DOI10.1002/ajh.23434