Title | Genetic studies of fetal hemoglobin in the Arab-Indian haplotype sickle cell-β(0) thalassemia. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Alsultan, A, Ngo, D, Bae, H, Sebastiani, P, Baldwin, CT, Melista, E, Suliman, AM, Albuali, WH, Nasserullah, Z, Luo, H-yuan, Chui, DHK, Steinberg, MH, Al-Ali, AK |
Journal | American journal of hematology |
Volume | 88 |
Issue | 6 |
Pagination | 531-2 |
Date Published | 06/2013 |
Keywords | Polymorphism, Single Nucleotide |
Abstract | Independently of its African roots, the HbS gene is also indigenous to the Middle East and India where it can be on an Arab-Indian (AI) HBB haplotype. This haplotype is associated with high levels of fetal hemoglobin (HbF) and increased HbF improves many complications of sickle cell disease. 1 Polymorphisms in BCL11A (chr 2p) and HBS1L-MYB (chr 6q) and in elements linked to HBB (chr 11p) are associated with HbF level. In AI haplotype HbS homozygotes, SNPs in BCL11A and HBS1L-MYB accounted for 8.8% of HbF variance. |
DOI | 10.1002/ajh.23434 |