TitleExploring Data From Genetic Association Studies Using Bayesian Variable Selection and the Dirichlet Process: Application to Searching for Gene × Gene Patterns
Publication TypeJournal Article
Year of Publication2012
AuthorsPapathomas, M, Molitor, J, Hoggart, C, Hastie, D, Richardson, S
JournalGenetic Epidemiology
Pagination663 - 674
Date Published09/2012

We construct data exploration tools for recognizing important covariate patterns associated with a phenotype, with particular focus on searching for association with gene-gene patterns. To this end, we propose a new variable selection procedure that employs latent selection weights and compare it to an alternative formulation. The selection procedures are implemented in tandem with a Dirichlet process mixture model for the flexible clustering of genetic and epidemiological profiles. We illustrate our approach with the aid of simulated data and the analysis of a real data set from a genome-wide association study.