TitleExperiencing reproductive concerns as a female cancer survivor is associated with depression.
Publication TypeJournal Article
Year of Publication2015
AuthorsGorman, JR, H Su, I, Roberts, SC, Dominick, SA, Malcarne, VL
JournalCancer
Volume121
Issue6
Pagination935-42
Date Published2015 Mar 15
ISSN1097-0142
KeywordsAdolescent, Adult, Cross-Sectional Studies, Depression, Female, Humans, Neoplasms, Quality of Life, Reproduction, Risk Factors, Surveys and Questionnaires, Survivors, Young Adult
Abstract
 

BACKGROUND: Young adult female cancer survivors have unmet reproductive concerns and informational needs that are associated with poorer quality of life. The purpose of this study was to examine the association between current reproductive concerns and moderate to severe depression among young survivors.

METHODS: This cross-sectional study included 200 female cancer survivors between the ages of 18 and 35 years who completed a Web-based survey measuring reproductive history, parenthood desires, reproductive concerns after cancer, and quality-of-life indicators.

RESULTS: The mean age of the participants was 28 years (standard deviation, 4.4 years), and almost two-thirds were diagnosed within 5 years of survey completion. A multivariate logistic regression analysis controlling for education, duration of survivorship, and social support revealed an association between experiencing reproductive concerns and moderate to severe depression (odds ratio for each 5-unit increase in the Reproductive Concerns After Cancer [RCAC] score, 1.30; 95% confidence interval, 1.06-1.60). Among those with moderate to severe depression, 23% had high RCAC scores, whereas 6% of those with minimal to mild depression did (P < .001).

CONCLUSIONS: A higher level of reproductive concerns was associated with greater odds of experiencing moderate to severe depression. Almost a quarter of survivors in this sample reported moderate to severe depression, and addressing reproductive concerns represents one potential area of intervention for improving the psychosocial health of young survivors.

DOI10.1002/cncr.29133
Alternate JournalCancer
PubMed ID25377593
PubMed Central IDPMC4352116
Grant ListK23 HD058799 / HD / NICHD NIH HHS / United States
U54 CA132379 / CA / NCI NIH HHS / United States
U54 CA132384 / CA / NCI NIH HHS / United States