Title | Enhancement of anaerobic glycolysis - a role of PGC-1α4 in resistance exercise. |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | Koh, J-H, Pataky, MW, Dasari, S, Klaus, KA, Vuckovic, I, Ruegsegger, GN, KUMAR, ARATHIPRABHA, Robinson, MM, K Nair, S |
Journal | Nat Commun |
Volume | 13 |
Issue | 1 |
Pagination | 2324 |
Date Published | 04/2022 |
ISSN | 2041-1723 |
Keywords | Anaerobiosis, Glycolysis, Humans, PPAR-beta, Resistance Training, Transcription Factors |
Abstract | Resistance exercise training (RET) is an effective countermeasure to sarcopenia, related frailty and metabolic disorders. Here, we show that an RET-induced increase in PGC-1α4 (an isoform of the transcriptional co-activator PGC-1α) expression not only promotes muscle hypertrophy but also enhances glycolysis, providing a rapid supply of ATP for muscle contractions. In human skeletal muscle, PGC-1α4 binds to the nuclear receptor PPARβ following RET, resulting in downstream effects on the expressions of key glycolytic genes. In myotubes, we show that PGC-1α4 overexpression increases anaerobic glycolysis in a PPARβ-dependent manner and promotes muscle glucose uptake and fat oxidation. In contrast, we found that an acute resistance exercise bout activates glycolysis in an AMPK-dependent manner. These results provide a mechanistic link between RET and improved glucose metabolism, offering an important therapeutic target to counteract aging and inactivity-induced metabolic diseases benefitting those who cannot exercise due to many reasons. |
DOI | 10.1038/s41467-022-30056-6 |
Alternate Journal | Nat Commun |
PubMed ID | 35484130 |
PubMed Central ID | PMC9050893 |