|Title||Duration of depressive symptoms and mortality risk: the English Longitudinal Study of Ageing (ELSA).|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||White, J, Zaninotto, P, Walters, K, Kivimäki, M, Demakakos, P, Biddulph, J, Kumari, M, De Oliveira, C, Gallacher, J, Batty, GD|
|Journal||Br J Psychiatry|
|Keywords||Aging, Case-Control Studies, Depression, England, Female, Humans, Longitudinal Studies, Male, Middle Aged, Registries, Risk Factors, Time Factors|
BACKGROUND: The relationship between the duration of depressive symptoms and mortality remains poorly understood.
AIMS: To examine whether the duration of depressive symptoms is associated with mortality risk.
METHOD: Data (n= 9560) came from the English Longitudinal Study of Ageing (ELSA). We assessed depressive symptom duration as the sum of examinations with an eight-item Center for Epidemiologic Studies Depression Scale score of ⩾3; we ascertained mortality from linking our data to a national register.
RESULTS: Relative to those participants who never reported symptoms, the age- and gender-adjusted hazard ratios for elevated depressive symptoms over 1, 2, 3 and 4 examinations were 1.41 (95% CI 1.15-1.74), 1.80 (95% CI 1.44-2.26), 1.97 (95% CI 1.57-2.47) and 2.48 (95% CI 1.90-3.23), respectively (Pfor trend <0.001). This graded association can be explained largely by differences in physical activity, cognitive function, functional impairments and physical illness.
CONCLUSIONS: In this cohort of older adults, the duration of depressive symptoms was associated with mortality in a dose-response manner.
|Alternate Journal||Br J Psychiatry|
|PubMed Central ID||PMC4816969|
|Grant List||R01 HL036310 / HL / NHLBI NIH HHS / United States |
K013351 / / Medical Research Council / United Kingdom
R01 AG034454 / AG / NIA NIH HHS / United States
MR/K026992/1 / / Medical Research Council / United Kingdom
MR/K023233/1 / / Medical Research Council / United Kingdom
MR/KO232331/1 / / Medical Research Council / United Kingdom
R01 AG017644 / AG / NIA NIH HHS / United States
MR/K013351/1 / / Medical Research Council / United Kingdom
WT087640MA / / Wellcome Trust / United Kingdom
R01AG034454 / AG / NIA NIH HHS / United States
R01HL036310 / HL / NHLBI NIH HHS / United States