TitleDuration of depressive symptoms and mortality risk: the English Longitudinal Study of Ageing (ELSA).
Publication TypeJournal Article
Year of Publication2016
AuthorsWhite, J, Zaninotto, P, Walters, K, Kivimäki, M, Demakakos, P, Biddulph, J, Kumari, M, De Oliveira, C, Gallacher, J, Batty, GD
JournalBr J Psychiatry
Volume208
Issue4
Pagination337-42
Date Published04/2016
ISSN1472-1465
KeywordsAging, Case-Control Studies, Depression, England, Female, Humans, Longitudinal Studies, Male, Middle Aged, Registries, Risk Factors, Time Factors
Abstract
 

BACKGROUND: The relationship between the duration of depressive symptoms and mortality remains poorly understood.

AIMS: To examine whether the duration of depressive symptoms is associated with mortality risk.

METHOD: Data (n= 9560) came from the English Longitudinal Study of Ageing (ELSA). We assessed depressive symptom duration as the sum of examinations with an eight-item Center for Epidemiologic Studies Depression Scale score of ⩾3; we ascertained mortality from linking our data to a national register.

RESULTS: Relative to those participants who never reported symptoms, the age- and gender-adjusted hazard ratios for elevated depressive symptoms over 1, 2, 3 and 4 examinations were 1.41 (95% CI 1.15-1.74), 1.80 (95% CI 1.44-2.26), 1.97 (95% CI 1.57-2.47) and 2.48 (95% CI 1.90-3.23), respectively (Pfor trend <0.001). This graded association can be explained largely by differences in physical activity, cognitive function, functional impairments and physical illness.

CONCLUSIONS: In this cohort of older adults, the duration of depressive symptoms was associated with mortality in a dose-response manner.

DOI10.1192/bjp.bp.114.155333
Alternate JournalBr J Psychiatry
PubMed ID26795425
PubMed Central IDPMC4816969
Grant ListR01 HL036310 / HL / NHLBI NIH HHS / United States
K013351 / / Medical Research Council / United Kingdom
R01 AG034454 / AG / NIA NIH HHS / United States
MR/K026992/1 / / Medical Research Council / United Kingdom
MR/K023233/1 / / Medical Research Council / United Kingdom
MR/KO232331/1 / / Medical Research Council / United Kingdom
R01 AG017644 / AG / NIA NIH HHS / United States
MR/K013351/1 / / Medical Research Council / United Kingdom
WT087640MA / / Wellcome Trust / United Kingdom
R01AG034454 / AG / NIA NIH HHS / United States
R01HL036310 / HL / NHLBI NIH HHS / United States