TitleDoes overall diet in midlife predict future aging phenotypes? A cohort study.
Publication TypeJournal Article
Year of Publication2013
AuthorsAkbaraly, T, Sabia, S, Hagger-Johnson, G, Tabák, AG, Shipley, MJ, Jokela, M, Brunner, EJ, Hamer, M, Batty, GD, Singh-Manoux, A, Kivimäki, M
JournalAm J Med
Volume126
Issue5
Pagination411-419.e3
Date Published2013 May
ISSN1555-7162
KeywordsAdult, Aged, Aging, Cardiovascular Diseases, Cohort Studies, Diet, Feeding Behavior, Female, Follow-Up Studies, Health Behavior, Humans, Male, Middle Aged, Outcome Assessment (Health Care), Patient Compliance, Phenotype, Risk
Abstract

BACKGROUND: The impact of diet on specific age-related diseases has been studied extensively, but few investigations have adopted a more holistic approach to determine the association of diet with overall health at older ages. We examined whether diet, assessed in midlife, using dietary patterns and adherence to the Alternative Healthy Eating Index (AHEI), is associated with aging phenotypes, identified after a mean 16-year follow-up.

METHODS: Data were drawn from the Whitehall II cohort study of 5350 adults (age 51.3±5.3 years, 29.4% women). Diet was assessed at baseline (1991-1993). Mortality, chronic diseases, and functioning were ascertained from hospital data, register linkage, and screenings every 5 years and were used to create 5 outcomes at follow-up: ideal aging (free of chronic conditions and high performance in physical, mental, and cognitive functioning tests; 4%), nonfatal cardiovascular event (12.7%), cardiovascular death (2.8%), noncardiovascular death (7.3%), [corrected] and normal aging (73.2%).

RESULTS: Low adherence to the AHEI was associated with an increased risk of cardiovascular and noncardiovascular death. In addition, participants with a "Western-type" diet (characterized by high intakes of fried and sweet food, processed food and red meat, refined grains, and high-fat dairy products) had lower odds of ideal aging (odds ratio for top vs bottom tertile: 0.58; 95% confidence interval, 0.36-0.94; P=.02), independently of other health behaviors.

CONCLUSIONS: By considering healthy aging as a composite of cardiovascular, metabolic, musculoskeletal, respiratory, mental, and cognitive function, the present study offers a new perspective on the impact of diet on aging phenotypes.

DOI10.1016/j.amjmed.2012.10.028
Alternate JournalAm. J. Med.
PubMed ID23582933
PubMed Central IDPMC3743043
Grant List / / British Heart Foundation / United Kingdom
RG/13/2/30098 / / British Heart Foundation / United Kingdom
R01 HL036310 / HL / NHLBI NIH HHS / United States
G19/35 / / Medical Research Council / United Kingdom
G0100222 / / Medical Research Council / United Kingdom
G0902037 / / Medical Research Council / United Kingdom
R01 AG034454 / AG / NIA NIH HHS / United States
G8802774 / / Medical Research Council / United Kingdom
R01 AG013196 / AG / NIA NIH HHS / United States
HS06516 / HS / AHRQ HHS / United States
R01AG034454 / AG / NIA NIH HHS / United States
R01HL036310 / HL / NHLBI NIH HHS / United States
R01AG013196 / AG / NIA NIH HHS / United States
RG/07/008/23674 / / British Heart Foundation / United Kingdom