TitleDoes the Framingham cardiovascular disease risk score also have predictive utility for dementia death? An individual participant meta-analysis of 11,887 men and women.
Publication TypeJournal Article
Year of Publication2013
AuthorsRuss, TC, Hamer, M, Stamatakis, E, Starr, JM, Batty, GD, Kivimäki, M
JournalAtherosclerosis
Volume228
Issue1
Pagination256-8
Date Published2013 May
ISSN1879-1484
KeywordsAdult, Aged, Cardiovascular Diseases, Cohort Studies, Dementia, Female, Humans, Male, Massachusetts, Middle Aged, Predictive Value of Tests, Proportional Hazards Models, Risk Factors
Abstract

OBJECTIVE: Individual cardiovascular disease (CVD) risk factors are associated with dementia. For the first time, we investigated whether the Framingham CVD risk score-which comprises these multiple risk factors-was also associated with future dementia risk.

METHODS: Individual participant meta-analysis of two large, general population cohort studies (N = 11,887). For the purposes of comparison of the dementia results, we also examined the association between the Framingham CVD risk score and CVD-related death.

RESULTS: Framingham CVD risk score was associated with dementia death (hazard ratio per 10% increased risk, 95% confidence interval: 4.00, 2.44-6.56). Adjusting for age eliminated this association (1.04, 0.53-2.01); similarly, age explained 88% of the ability of the Framingham CVD risk score to predict CVD death.

CONCLUSIONS: The Framingham CVD risk score was no more strongly associated with future dementia than age. It therefore offers no added value in predicting dementia.

DOI10.1016/j.atherosclerosis.2013.02.020
Alternate JournalAtherosclerosis
PubMed ID23477745
Grant ListRG/13/2/30098 / / British Heart Foundation / United Kingdom
K013351 / / Medical Research Council / United Kingdom
MR/K026992/1 / / Medical Research Council / United Kingdom
G0700704/84698 / / Medical Research Council / United Kingdom
PG/11/63/29011 / / British Heart Foundation / United Kingdom
G0700704 / / Medical Research Council / United Kingdom
R01AG034454 / AG / NIA NIH HHS / United States
R01HL036310 / HL / NHLBI NIH HHS / United States