TitleDietary soy and tea mitigate chronic inflammation and prostate cancer via NFκB pathway in the Noble rat model.
Publication TypeJournal Article
Year of Publication2011
AuthorsHsu, A, Bruno, RS, Löhr, CV, Taylor, AW, Dashwood, RH, Bray, TM, Ho, E
JournalJ Nutr Biochem
Date Published05/2011
KeywordsAnimals, Anti-Inflammatory Agents, Antineoplastic Agents, bcl-2-Associated X Protein, Catechin, Chronic Disease, Diet, Disease Models, Animal, Estradiol, I-kappa B Proteins, Inflammation, Interleukin-1beta, Interleukin-6, Isoflavones, Male, NF-kappa B, NF-KappaB Inhibitor alpha, Prostatic Neoplasms, Rats, Signal Transduction, Soy Foods, Soybeans, Tea, Testosterone, Tumor Necrosis Factor-alpha

Chronic inflammation and nuclear factor-kappa B (NFκB) have been implicated in prostate cancer development; thus, dietary factors that inhibit NFκB may serve as effective chemo-preventative agents. Prostate cancer risk is significantly lower in Asian countries compared to the United States, which has prompted interest in the potential chemopreventative action of Asian dietary components such as soy and green tea. This study examined the effects of dietary soy and tea on NFκB activation and inflammation in vivo using a hormone-induced rat model for prostate cancer. Male Noble rats implanted with estradiol and testosterone were divided into 4 dietary groups: control, soy, tea, or soy+tea. NFκB activation and inflammatory cytokines were measured post implantation. The combination of soy and tea suppressed NFκB p50 binding activity and protein levels via induction of IκBα. Soy and tea also decreased prostate inflammatory infiltration, increased Bax/BcL2 ratio and decreased protein expression of tumor necrosis factor-alpha, interleukin (IL)-6 and IL-1β compared to control. Soy and tea attenuated prostate malignancy by decreasing prostate hyperplasia. These effects were not apparent in groups treated with soy or tea alone. The ongoing in vivo studies thus far suggest that combination of foods, such as soy and tea, may inhibit hormone-induced proinflammatory NFκB signals that contribute to prostate cancer development.

Alternate JournalJ. Nutr. Biochem.
PubMed ID20801632
PubMed Central IDPMC2995825
Grant ListP01 CA090890 / CA / NCI NIH HHS / United States
P30 ES00210 / ES / NIEHS NIH HHS / United States
CA107693 / CA / NCI NIH HHS / United States
R01 CA107693 / CA / NCI NIH HHS / United States
R01 CA107693-05 / CA / NCI NIH HHS / United States
CA909890 / CA / NCI NIH HHS / United States
P30 ES000210 / ES / NIEHS NIH HHS / United States