TitleCommon genetic variants explain the majority of the correlation between height and intelligence: the generation Scotland study.
Publication TypeJournal Article
Year of Publication2014
AuthorsMarioni, RE, Batty, GD, Hayward, C, Kerr, SM, Campbell, A, Hocking, LJ, Porteous, DJ, Visscher, PM, Deary, IJ
Corporate AuthorsGeneration Scotland
JournalBehav Genet
Volume44
Issue2
Pagination91-6
Date Published2014 Mar
ISSN1573-3297
KeywordsAdult, Aged, Body Height, Cohort Studies, Female, Genetic Variation, Genotype, Humans, Intelligence, Male, Middle Aged, Oligonucleotide Array Sequence Analysis, Phenotype, Scotland
Abstract

Greater height and higher intelligence test scores are predictors of better health outcomes. Here, we used molecular (single-nucleotide polymorphism) data to estimate the genetic correlation between height and general intelligence (g) in 6,815 unrelated subjects (median age 57, IQR 49-63) from the Generation Scotland: Scottish Family Health Study cohort. The phenotypic correlation between height and g was 0.16 (SE 0.01). The genetic correlation between height and g was 0.28 (SE 0.09) with a bivariate heritability estimate of 0.71. Understanding the molecular basis of the correlation between height and intelligence may help explain any shared role in determining health outcomes. This study identified a modest genetic correlation between height and intelligence with the majority of the phenotypic correlation being explained by shared genetic influences.

DOI10.1007/s10519-014-9644-z
Alternate JournalBehav. Genet.
PubMed ID24554214
PubMed Central IDPMC3938855
Grant ListCZD/16/6/4 / / Chief Scientist Office / United Kingdom
G0100266 / / Medical Research Council / United Kingdom
MR/K026992/1 / / Medical Research Council / United Kingdom