TitleCommentary: Antidepressants and diabetes risk: why are there discrepant findings from cohort studies based on patient records and those based on serial phenotyping?
Publication TypeJournal Article
Year of Publication2015
AuthorsKivimäki, M, Batty, GD
JournalInt J Epidemiol
Date Published12/2015
KeywordsAntidepressive Agents, Cohort Studies, Diabetes Mellitus, Humans, Medical Records, Risk

The potentially harmful effects of antidepressants, one of the most prescribed groups of drugs worldwide, have been the subject of some debate. In 2004, the US Food and Drug Administration issued a ‘black-box’ warning on antidepressants (so called because the advisory text on the package insert is required to be framed by a black border), after its own systematic review indicated that such therapy was associated with an elevated risk of suicidal thinking, feeling and behaviour in young people. 1,2 In this issue of the International Journal of Epidemiology , Azevedo Da Silva and co-workers make a timely and important contribution to the evidence base for another controversial potential side effect: antidepressant medication might predispose individuals to type 2 diabetes. 3

Alternate JournalInt J Epidemiol
PubMed ID26371208
PubMed Central IDPMC4690001
Grant ListMR/K013351/1 / / Medical Research Council / United Kingdom