TitleChildhood cancer among twins and higher order multiples.
Publication TypeJournal Article
Year of Publication2009
AuthorsPuumala, SE, Carozza, SE, Chow, EJ, Fox, EE, Horel, S, Johnson, KJ, McLaughlin, C, Mueller, BA, Reynolds, P, Von Behren, J, Spector, LG
JournalCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Date Published2009 Jan
KeywordsWilms Tumor

Although several studies have found no change or a decreased risk of childhood cancer in twins, few have controlled for potential confounders such as birth weight. We examined the association of birth plurality and childhood cancer in pooled data from five U.S. states (California, Minnesota, New York, Texas, and Washington) using linked birth-cancer registry data. The data, excluding children with Down syndrome or who died before 28 days of life, included 17,672 cases diagnosed from 1980 to 2004 at ages 28 days to 14 years and 57,966 controls with all cases and controls born from 1970 to 2004. Analyses were restricted to children weighing