TitleBCL11B regulates sutural patency in the mouse craniofacial skeleton.
Publication TypeJournal Article
Year of Publication2016
AuthorsKyrylkova, K, Iwaniec, UT, Philbrick, KA, Leid, M
JournalDev Biol
Volume415
Issue2
Pagination251-60
Date Published2016 Jul 15
ISSN1095-564X
Abstract
 

The transcription factor BCL11B plays essential roles during development of the immune, nervous, and cutaneous systems. Here we show that BCL11B is expressed in both osteogenic and sutural mesenchyme of the developing craniofacial complex. Bcl11b(-/-) mice exhibit increased proliferation of osteoprogenitors, premature osteoblast differentiation, and enhanced skull mineralization leading to synostoses of facial and calvarial sutures. Ectopic expression of Fgfr2c, a gene implicated in craniosynostosis in mice and humans, and that of Runx2 was detected within the affected sutures of Bcl11b(-/-) mice. These data suggest that ectopic expression of Fgfr2c in the sutural mesenchyme, without concomitant changes in the expression of FGF ligands, appears to induce the RUNX2-dependent osteogenic program and craniosynostosis in Bcl11b(-/-) mice.

DOI10.1016/j.ydbio.2015.10.010
Alternate JournalDev. Biol.
PubMed ID26453795
PubMed Central IDPMC4826646
Grant ListF06 TW002367 / TW / FIC NIH HHS / United States
R15 DE021879 / DE / NIDCR NIH HHS / United States