TitleAssortative Mating by Ethnicity in Longevous Families.
Publication TypeJournal Article
Year of Publication2017
AuthorsSebastiani, P, Gurinovich, A, Bae, H, Andersen, SL, Perls, TT
JournalFront Genet
Volume8
Pagination186
Date Published11/2017
ISSN1664-8021
Abstract
 

Recent work shows strong evidence of ancestry-based assortative mating in spouse pairs of the older generation of the Framingham Heart Study. Here, we extend this analysis to two studies of human longevity: the Long Life Family Study (LLFS), and the New England Centenarian Study (NECS). In the LLFS, we identified 890 spouse pairs spanning two generations, while in the NECS we used data from 102 spouse pairs including offspring of centenarians. We used principal components of genome-wide genotype data to demonstrate strong evidence of ancestry-based assortative mating in spouse pairs of the older generation and also confirm the decreasing trend of endogamy in more recent generations. These findings in studies of human longevity suggest that spouses marrying into longevous families may not be powerful controls for genetic association studies, and that there may be important ethnicity-specific, genetic influences and/or gene-environment interactions that influence extreme survival in old generations. In addition, the decreasing trend of genetic similarity of more recent generations might have ramifications for the incidence of homozygous rare variants necessary for survival to the most extreme ages.

DOI10.3389/fgene.2017.00186
Alternate JournalFront Genet
PubMed ID29209360
PubMed Central IDPMC5702482
Grant ListU01 AG023712 / AG / NIA NIH HHS / United States
U01 AG023749 / AG / NIA NIH HHS / United States
U01 AG023755 / AG / NIA NIH HHS / United States
U19 AG023122 / AG / NIA NIH HHS / United States