TitleAssociation of Systemic Inflammation With Risk of Completed Suicide in the General Population.
Publication TypeJournal Article
Year of Publication2016
AuthorsBatty, GD, Bell, S, Stamatakis, E, Kivimäki, M
JournalJAMA Psychiatry
Date Published08/2016
KeywordsC-Reactive Protein, Cause of Death, Comorbidity, Female, Follow-Up Studies, Humans, Inflammation, Male, Registries, Sex Factors, Smoking, Social Class, Stress, Psychological, Suicide, United Kingdom

There is a growing prima facie case for inflammation being associated with suicide. In cohort studies,1 elevated levels of inflammatory markers have been linked to the future occurrence of depression, a known risk factor for suicide. In psychiatric patients, inflammation is positively associated with the intensity of self-reported suicidal ideation,2 and those who commit suicide have higher cytokine levels post mortem relative to control patients.3 Furthermore, individuals with asthma, a condition characterized by inflammation, experience higher rates of suicide mortality than their nonatopic counterparts.4

While these various lines of evidence may implicate inflammation in the pathophysiology of suicide, there has been no prospective examination of the link between inflammation and future suicide events.

Alternate JournalJAMA Psychiatry
PubMed ID27532220
Grant ListMR/K013351/1 / / Medical Research Council / United Kingdom
MR/K026992/1 / / Medical Research Council / United Kingdom