TitleAssociation of inflammation with specific symptoms of depression in a general population of older people: The English Longitudinal Study of Ageing.
Publication TypeJournal Article
Year of Publication2017
AuthorsWhite, J, Kivimäki, M, Jokela, M, Batty, GD
JournalBrain Behav Immun
Date Published03/2017
KeywordsAged, Aging, Antidepressive Agents, Biomarkers, C-Reactive Protein, Depression, England, Female, Humans, Inflammation, Longitudinal Studies, Male, Middle Aged

Elevated levels of inflammatory markers, such as C-reactive protein, are well documented in people with depression. Few studies have examined whether the association between inflammation and depression is symptom specific, and differs according to antidepressant treatment. Using data from the English Longitudinal Study of Ageing (N=5909), cross-sectional analyses revealed a significant dose-response association between C-reactive protein and the symptoms of fatigue (P<0.001), restless sleep (P=0.03), low energy (P=0.02) and feeling depressed (P=0.04), but not other symptoms. These associations were absent in users of anti-depressant medication. Our findings suggest the C-reactive protein-depression association is symptom-specific and modified by antidepressant treatment.

Alternate JournalBrain Behav. Immun.
PubMed ID27562420
Grant ListMR/K013351/1 / / Medical Research Council / United Kingdom
MR/K026992/1 / / Medical Research Council / United Kingdom
PG/11/63/29011 / / British Heart Foundation / United Kingdom
RG/13/2/30098 / / British Heart Foundation / United Kingdom